Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Structure Modeling"”.
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New Methods to Improve Protein Structure Modeling
… in every living cell. Understanding protein structures and functions will lead to a significant advance in life science and biology. Such knowledge is vital for various fields such as drug development and synthetic biofuels production.</p> <p>Most proteins have definite shapes that they fold …
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Improving Structural Features Prediction in Protein Structure Modeling
… and energetically favorable three-dimensional structure which is critical to its biological function. Hence, there has been a great effort by researchers in both experimentally determining and computationally predicting the structures of proteins.</p> <p>The current experimental methods of …
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Parametric Soil-Structure Modeling for Rapid Climatic Disaster Response
… for efficient tools that can analyze coastal structures that take a system modeling approach. Such a system approach should consider structuresthat are subjected to a combination of extreme forces and changes of boundary conditions, which may include hydrodynamic wave effects, hydraulic …
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De Novo Protein Structure Modeling and Energy Function Design
<p>The two major challenges in protein structure prediction problems are (1) the lack of an accurate energy function and (2) the lack of an efficient search algorithm. A protein energy function accurately describing the interaction between residues is able to supervise the optimization of a protein …
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Protein kinases: Structure modeling, inhibition, and protein-protein interactions
… do not yet have an available X-ray crystal structure and have not yet been validated to be drug targets. For these reasons, we developed a new homology modeling approach to facilitate modeling non-crystallized protein kinases and protein kinase states. Our homology modeling approach was able …
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Developing Advanced Representation Learning Techniques for mRNA Sequence and Structure Modeling
… lengths, and multiple isoforms. Accurately modeling these sequences is essential for predicting mRNA degradation, a key factor in designing effective RNA-based therapies. However, many existing models struggle to capture the intricate relationships between sequence and structure, limiting …
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Algorithmic Developments for Sequence Analysis, Structure Modeling and Functional Prediction of Proteins
Sequence, structure and function, being the three most important properties of proteins, are interrelated through homology relationships. In this post-genome era, we are equipped with abundant sequence information. Homology inference is thus of great practical importance because of its ability to …
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A Finite Mixture Approach to Covariance Structure Modeling With Unknown, Heterogeneous Populations
"The field of covariance structure modeling has included models for heterogeneous populations for some time (e.g., Muthen, 1989), but to date none have incorporated methods that allow for heterogeneity when the population membership is unknown. The field of finite mixture analysis, however, …
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De Novo Protein Structure Modeling from Cryoem Data Through a Dynamic Programming Algorithm in the Secondary Structure Topology Graph
… and energetically favorable 3-Dimensional (3-D) structure which is critical and unique to its biological function. In contrast to other methods for protein structure determination, Electron Cryorricroscopy (CryoEM) is able to produce volumetric maps of proteins that are poorly soluble, large and …
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Machine Learning and Optimization Algorithms for Intra- and Intermolecular Interaction Prediction
… information, thus limiting their predictive modeling accuracy. Hence, my objectives include (1) the development of computational methods for protein structure modeling through the estimation of intra-protein interactions, (2) the development of computational methods for predicting protein- …
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Protein Structure Analysis and Prediction
The protein structure prediction problem consists of three separate subproblems: modeling the protein structure, modeling the protein energetics, and the problem of searching for low-energy structures in high-dimensional space in the presence of many local minima. This study presents a new approach …
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An Investigation Into Splicing Variation and Expression Patterns of Insulin-Like Peptide 4 (ILP4) Within the Drosophila Genus
… extra glutamic acid residue in the final protein structure. Initial analysis suggests that this variation may not significantly impact ILP4 functionality, but additional studies, such as protein structure modeling and function analysis, are necessary. Further identified is significant variation in …
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Hierarchical music structure analysis, modeling and resynthesis : a dynamical systems and signal processing approach
… algorithms, the second is based on the idea of modeling and generalizing from preexistent music for the subsequent generation of new pieces. Most inductive models developed in the past have been probabilistic, while the majority of the deductive approaches have been rule based, some of them with …
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Vector-valued multidimensional signal processing and analysis in the context of fluid flows
… issue in this thesis is the analysis of vortex structures in turbulent fluid flows. A framework for identifying regions of vortices is established, which contains vortex structure modeling, pointwise linear approximation of flow fields, local fluid motion classification, and vortex structure …
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Emotional Intelligence at Mid Life: A Cross Sectional Investigation of Structural Variance, Social Correlates, and Relationship to Established Personality and Ability Taxonomies
… disadvantages of factor-analytic and covariance structure modeling methodology. Implications, particularly for psychotherapy with each age group, are discussed.
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Analytical Solutions of the SABR Stochastic Volatility Model
… studies a mathematical problem that arises in modeling the prices of option contracts in an important part of global financial markets, the fixed income option market. Option contracts, among other derivatives, serve an important function of transferring and managing financial risks in today's …
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The “Identity Biennial” & the Politics of the Interstice
… to order and hold together the narrative structure, modeling the contingency and negotiation of inner and outer relationality of Varela’s Chicano personal cinema. For Gandert, the empty spaces and borderlines separating each picture in the series become a hinge between individuals that …
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Structure determination of a yeast ribosomal protein L30 and pre-mRNA binding site complex by NMR spectroscopy
… of the G 11G56 reverse Hoogsteen mismatch pair. Structure modeling using simulated annealing in restrained molecular dynamics was carried out in X-PLOR. Detailed analyses of the complex structure reveal that the protein recognizes the RNA mostly along one side of the internal loop with five …
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Structural Characterization and <em>in vitro</em> Antiproliferative Activity of Non-Specific Lipid Transfer Protein 1 (nsLTP1) from Fennel (<em>Foeniculum vulgare</em>) Seeds
… microbes. Even though the primary and spatial structures of some nsLTPs from different plants indicate their similar features, they exhibit distinct lipid-binding specificities signifying their various biological roles that dictate further structural study. The present study determined the …
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