Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Structure Based Docking"”.
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Insights into the Development of Chemotherapeutics Targeting PFKFB Enzymes
… work investigates the potential for using tier-based approaches of virtual screening to target small molecule kinases, with PFKFB3 serving as a case study. For this investigation, bioactive compounds for PFKFB3 were identified from a compound library of 1364 compounds via high-throughput …
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Structural investigation of 1,8-dinitro-4,5-dihydroxyanthraquinone and implications for docking as a small molecule inhibitor into the protease of West Nile virus
… viruses while also reducing their titers in cell-based assays. Structure-based analog design will likely be performed in the near future to increase its activity. However, the binding mechanism and conformation of the lead is unknown. The virtual screen that discovered this inhibitor showed it as …