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Showing 1 to 20 of 48 for “"Structural determination"”.
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Utility of Ion Mobility – Mass Spectrometry in Peptidoglycan Structural Determination
… spectrometry as a tool to provide muropeptide structural information through analysis of ion mobilities and collision cross section (CCS). PG of two filamentous cyanobacteria, Nostoc commune and Limnospira platensis, were chosen for this work as they have not been characterized before now …
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NOVEL MICROTUBULE TARGETING AGENTS: SYNTHESIS AND STRUCTURAL DETERMINATION OF THEIR INTERACTIONS
… by the X-ray crystallography structure determination of individual tubulin-compound complexes, which was performed in the course of my one-year secondment period at the Paul Scherrer Institute. Based on that, Chapter II covers the synthetic part of the work, while Chapter III covers …
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Towards Establishing Methods of Synthesis, Purification, and Structural Determination for Human Fibrinogen
… its polymerizable form, fibrin, it serves as the structural component of blood clots and helps to incorporate red blood cells, macrophages, and fibroblasts to the wound-site. Fibrinogen plays important roles in inflammation and tissue regeneration, regulating growth factor receptor pathway …
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Structural Determination of the novel Universal Stress Protein G4LZI3 from Shistosoma mansoni using X-ray Crystallography
Structural determination of the novel Universal Stress Protein G4LZI3 from Schistosoma mansoni using X-ray Crystallography Priscilla Masamba PhD (Biochemistry) thesis, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand Schistosoma mansoni is a …
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Extraction, isolation and structural determination of organic compounds from Scaevola spinescens R.Br. / by Sally Felstead Nobbs.
Scaevola spinescens is an Australian native plant, found widely in the arid to semi-arid regions of South Australia and through into most other states. Aboriginal people of Hawker in South Australia have traditionally used it as a natural medicine to treat a variety of symptoms. The thesis aims to …
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Study of the Interplay Among Non -Covalent Interactions in Structural Determination of Gas Phase Cluster Ions
… the most labile species and therefore a possible structural change. In the vibrational spectra of Li+(Benzene)n(Water)1--4 clusters, pi-H bonding bands dominated, while water-water hydrogen bonding features dominated the spectra of Cs+(Benzene)n(Water)1--4 clusters. The lithium ion retains a full …
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Structural Determination of Copolymers from the Cross-catalyzed Reactions of Phenol-formaldehyde and Polymeric Methylenediphenyl Diisocyanate
… spectroscopic studies generated real time structural information for model compound reactions of the cross-catalyzed system, differentiating among reaction peaks generated by the carbamic acid reaction, PU and BU formation. ATR-FTIR also permitted monitoring of propylene carbonate …
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The optical resolution of albuterol
… its (R)-Mosher ester, and confirmed by an X-ray structural determination of its (R)-phenylethylurea derivative. The acetonide derivative of (rac)-albuterol has been prepared and used as a substrate in cocrystallisation experiments with several acidic resolving agents~ Successful resolution of the …
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Structural Analysis of Carbohydrates by Mass Spectrometry
… the structure of an unknown glycan, 5 levels of structural information is needed: sugar unit identity, anomeric configuration, linkage types, sequence, and branching location. One of the grand challenges limiting the advance of glycosciences is the lack of sensitive tools for detailed glycan …
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Oligosaccharide Analysis via Anion Attachment Using Negative Mode Electrospray (ES) and Matrix Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry
… anions, CID of adduct species may be used for structural determination of neutral oligosaccharides. In the presence of F- and Ac-, simultaneous detection of acidic oligosaccharides and neutral oligosaccharides was achieved. The ratio of Cl- : non-Cl-containing product ions obtained in CID …
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Towards the Total Synthesis of Spirastrellolide E: Investigations into Advanced Southern Hemisphere Fragments
… is reported. Chapter 1 details the isolation, structural determination, and biological activity of the spirastrellolide family, as well as synthetic efforts towards members of the family. Chapter 2 describes the evolution of the Smith group synthetic strategy towards the spirastrellolides, …
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Deep Learning for Segmentation Of 3D Cryo-EM Images
… is an emerging biophysical technique for structural determination of protein complexes. However, accurate detection of secondary structures is still challenging when cryo-EM density maps are at medium resolutions (5-10 Å). Most existing methods are image processing methods that do not …
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Enhanced NMR Detection of Mass -Limited Samples With Microcoil Probes: Increasing Sample Throughput and Improved on-Line Coupling to Microscale Separations
Providing structural data unattainable by any other method, nuclear magnetic resonance (NMR) spectroscopy stands as an integral component of the modern academic and industrial chemical laboratory. The development of microcoils enables NMR analysis of small-volume, mass-limited samples. With their …
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A novel dermaseptin peptide from the defensive skin secretion of Phyllomedusa camba
… synthesis and after the cleavage reaction, the structural determination was performed through the use of MALDI-TOF mass spectrometry and purity was determined by RP-HPLC. In order to perform functional research, including antimicrobial assays and haemolysis assay, it was necessary to purify the …
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Machine learning for cryo-EM structure determination
… cryo-microscopy (cryo-EM) has revolutionised structural biology thanks to its relaxed sample requirements. Recent advances in cryo-EM image processing have enabled the structural determination of many macromolecules that were previously intractable by other methods. At the same time, …
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RNA Backbone Rotamers and Chiropraxis
… but has historically been a challenge in structural determination. It has many atoms and torsions to place, and often there is less data on it than one might wish. This problem leads to both random and systematic error, producing noise in an already high-dimensional and complex …
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Investigating the Effects of Glycochenodeoxycholic Acid on Mutant Murine Norovirus P-Domain Structure and Antibody Interactions
… and image reconstruction were used for structural determination of the MNV isolate, WU23. In the presence of GCDCA, we found variable dynamics across dimer pairs A/B and C/C. This result may support our hypothesis that WU23 is less sensitive to gastrointestinal cofactors such as bile …
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Insights into BTB-Cul3 Ubiquitin Ligases from the Structures of SPOP-Substrate Complexes
… ubiquitination. Here we present biochemical and structural analyses of the MATH and BTB domain containing protein, SPOP, which regulates diverse signaling pathways. First, we identified a conserved SPOP Binding Consensus (SBC) motif in the transcriptional regulator Ci, the protein phosphatase …
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