Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Structural classification"”.
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A structural classification of protein-protein interactions for detection of convergently evolved motifs and for prediction of protein binding sites on sequence level
… and how can knowledge be inferred from this classification such that protein interactions can be predicted for proteins without solved structure? The underlying hypothesis is that protein binding sites are often restricted to a small number of residues, which additionally often are …
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The early history and emergence of molecular functions and modular scale-free network behavior
The formation of protein structural domains requires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional loop (EFL) sequences and domain structures defined …
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Isolation and identification of an antimicrobial peptide with high anticancer activity and selectivity, QUB-2584 from the skin secretion of Litoria caerulea
… their bioactivities. Their various and complex structural classification, physical-chemical properties, and mechanism contributing to their bioactivities have been discovered and well understood. Here, we focus on a bioactive peptide named QUB-2584 derived from the skin secretion of Litoria …
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Studies on Combining Sequence and Structure for Protein Classification
… such principles of protein evolution. Manual classification schemes accurately group homologous proteins, but they are slow and subjective. Automatic protein clustering methods are largely based on sequence information. Therefore, they often do not accurately reflect remote homologies that can …
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Analysis of protein secondary structure via the discrete wavelet transform
… both a + B and a/B proteins coming from the Structural Classification of Proteins (SCOP) protein database. This data provides both protein primary sequences and secondary structure locations. In total, 13,435 individual proteins and nearly 15,511 unique protein subunits are analyzed. We use …
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Highly Accurate Fragment Library for Protein Fold Recognition
… computational methods fail to yield convincing structural homologies. In this work, we present a new protein fold recognition approach using machine learning and data mining methodologies.</p> <p>First, we identify a protein structural fragment library (Frag-K) composed of a set of backbone …
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Exploiting gene expression and protein data for predicting remote homology and tissue specificity
… accuracies in a benchmark task defined using the Structural Classification of Proteins (SCOP) database. While the task of predicting SCOP superfamilies should be regarded as an easy one, with not much room for performance improvement, it is still widely accepted as the gold standard due to careful …
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Patterns of somatic genome rearrangement in human cancer
… ranging from single point mutations to larger structural variants (SV) affecting kilobases to megabases of one or more chromosomes. Studies of somatic rearrangement have previously been limited by a paucity of whole genome sequencing data, and a lack of methods for comprehensive structural …
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A dynamic model for the evolution of protein structure
… trees of protein domains, defined using the Structural Classification of Proteins (SCOP), where the nodes are folds or fold superfamilies (FSFs), the character vector for each node is a list of abundances of said fold or FSF across a range of species that spans all three superkingdoms of …
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Nazwy miast i wsi w Bułgarii
Najważniejszym celem rozprawy pt. Nazwy miast i wsi w Bułgarii jest ukazanie, sklasyfikowanie i omówienie współczesnych nazw bułgarskich wsi i miast oraz zmian, jakie w nich zachodziły na przestrzeni wieków. We wprowadzeniu przedstawiłem cele i układ pracy oraz omówiłem obraną metodologię. Opisałem …