Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Structural and Molecular Biology"”.
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Modelling the structural, functional and phenotypic consequences of protein coding mutations
Proteins are integral to all cellular processes and underpin the function of all extant organisms, meaning variants impacting them are a primary cause of phenotypic variation. Protein coding variants are a key area of study in biology, with relevance from structural and molecular biology to …
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Sequence and structural analysis of antibodies
… in this thesis focusses on the sequence and structural analysis of antibodies and has fallen into three main areas. First I developed a method to assess how typical an antibody sequence is of the expressed human antibody repertoire. My hypothesis was that the more \humanlike" an antibody …
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
The interferon alpha receptor (IFNAR) and T-cell receptor (TCR) are expressed upon the T-cell surface. The dimeric Class I interferon receptor is a cytokine receptor that recognises interferons such as IFNα. Interferons (IFNs) are pluripotent, antiviral cytokines that causes antiproliferative …
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Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae
Chromosome rearrangements such as translocations and deletions are frequently associated with human cancers. Such rearrangement of the chromosome can be initiated by a DNA break (DSB) that, when inappropriately repaired, may alter chromosome structure. Mammalian common fragile sites are the …
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Structural and functional analysis of a phospho-dependent molecular switch: Rv1827 from Mycobacterium tuberculosis
… their precise roles in Ser/Thr kinase pathways and mechanisms of regulation remain unclear. From experiments with Rv1827, an FHA domain–containing protein from Mycobacterium tuberculosis, a complete molecular description of an FHA-mediated Ser/Thr protein kinase signalling process is derived. …
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Exploring the function and evolution of proteins using domain families
… distinct units which can be adapted and reused in other proteins. The classification of protein domains into evolutionary families facilitates the study of their evolution and function. In this thesis such classifications are used firstly to examine methods for identifying …
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Investigating the role of UDP-<i>N</i>-acetylhexosamine pyrophosphorylases in regulating <i>O</i>-GlcNAcylation in human disease
Modification of proteins on serine and threonine residues with O-linked N-acetyl-β-<sub>D</sub>glucosamine (O-GlcNAc) was first observed on the surface of lymphocytes in 1984. It was then found that over 1,000 nucleocytoplasmic proteins are modified by O-GlcNAc (O-GlcNAcylation). Interestingly, …