Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Structural Selectivity"”.
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DNA structural selectivity of binding by the Pol I DNA polymerases from Escherichia coli and Thermus aquaticus
… enzyme <I>in vivo</I>. Due to their sequence and structural similarities, Klenow and Klentaq, the “large fragments” of the Pol I DNA polymerases from <I>Escherichia coli</I> and <I>Thermus aquaticus</I>, are considered functional homologues. Klentaq, however, does not have a functional …
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Computer-Aided Drug Design of G-quadruplex Structures: Harnessing Polarization for Rational Drug Design
… and infectious diseases. However, the lack of structural selectivity in current GQ-targeting ligands has limited their clinical success. This dissertation focuses on improving the rational design of GQ-binding ligands by advancing computational methods that better capture the structural and …
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Exploring the molecular signatures of the ligand-receptor-Gi/o protein interactions of adenosine A1 and A3 receptors
… binding affinity, binding kinetics and subtype selectivity, several high-affinity candidates with about 10-fold improvement in affinity from their precursors were identified as hA3R-selective (e.g., 39), hA1R-selective (e.g., R1) or dual hA1R/hA3R antagonists (e.g., R8). Also, the binding pocket …