Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Structural Polymorphism"”.
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Structural Polymorphism in Tau Filaments: An Implication for Neurodegenerative Diseases
… resonance spectroscopy was used to obtain structural insights into tau filaments. The studies showed that the filaments of 4R tau and 3R tau share a highly ordered core structure in the third repeat with parallel, in-register arrangement of beta-strands. This structure in 3R and 4R is …
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Structural Polymorphism of Alpha-Synuclein in Conditions Resembling the Cellular Environment
… of the triggers for misfolding, and the structural transitions from the monomer to the fibrillar level in different cellular environmental conditions, to aid the better design of therapeutics in the future. To this aim, different environmental conditions were interrogated with regards to …
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Atomic Force Microscopic, Electron Spectroscopic Imaging and Molecular Simulation Investigations of the Assembly and Structures of Collagen Constructs
… order to understand the physical bases for the structural polymorphism observed in collagen, a good starting point is one of the simplest collagen aggregates, segmental long spacing (SLS) collagen. Although SLS collagen formation induced by the presence of adenosine 5’-triphosphate is widely …
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The Life of Prion: an investigation into the physiological role of a prion-like protein in the nematode Caenorhabditis elegans
… of proteins. Instead, these proteins display structural polymorphism, capable of adopting different conformations under different conditions; this expands the capabilities of protein function and represents a mechanism for epigenetic coding, with protein conformation possessing the ability …
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Structural Analysis of Reconstituted Collagen Type I - Heparin Cofibrils
… reconstituted ECMs, their interaction and structural characterization remains an intriguing conundrum. The aim of the work was to analyze and structurally characterize a xenogeneic in vitro cell culture scaffold reconstituted from two native ECM components, collagen type I and the highly …