Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Structural Mechanism"”.
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Structural mechanism for multidrug efflux systems
… and Neisseria gonorrhoeae have developed various mechanisms to overcome toxic environments that are otherwise unfavorable for their survival. One important strategy that bacteria use to expel toxic compounds, including heavy metal ions, is the expression of membrane efflux transporters that …
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Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation
… though MHCI contacts largely originate from structural regions unique to CPXV203. Structure-based mutations introduced into CPXV203 and MHCI validated the crystallographically-defined binding geometry and identified several binding and functional hotspots. These studies support that CPXV203 …
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The Structural Mechanism of Allosteric Modulation of The Nmda Receptor: A Balance of Tensions
… of neurological disorders. Studies targeting the mechanism of allosteric modulation, such as this study, hope to contribute to the understanding of how NMDA receptors are modulated to allow for better drug development.</p> <p>NMDA receptors are obligate heterotetramers, typically composed of …
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Structural mechanism of the recovery-stroke in Myosin II molecular motor at atomic detail
… z.B. die Muskelkontraktion zu ermoeglichen. Der Mechanismus dieser chemisch-mechanischen Kopplung, der fuer die Funktion von Myosin essenziell ist, ist nur in Ansaetzen verstanden. In dieser Arbeit wird ein rechnergesttzter Ansatz verwendet um den Mechanismus des recovery stroke'' zu verstehen. …
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Inelastic Analysis of Reinforced Concrete Beams Subjected to Combined Axial Force, Bending and Torsion
… the model in extreme conditions, the use of the structural mechanism of the space truss model is verified. The application of the models to some typical torsional problems suggests the conclusion that the existence of torsion may have significant influence on the response of the structure, …
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Characterization of structural changes in thermally enhanced Kevlar-29® Fiber
… exploratory investigation was to elucidate the structural mechanism accounting for the enhanced compressive properties of heat-treated Kevlar-29® fibers. A novel theory was set forth that hydrogen bond disruption and concurrent misorientation of crystallites may account for the observed …
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Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases
… A final project identified the structural mechanism that may explain the observed preference of EGFR-ErbB2 heterodimerization over EGFR homodimerization. Key residues were computationally predicted and biochemically tested to reveal critical dimerization interface.
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Design and development of a 7 degree-of-freedom powered exoskeleton for the upper limb
An exoskeleton is an external structural mechanism with joints and links corresponding to those of the human body. With applications in rehabilitation medicine and virtual reality simulation, exoskeletons offer benefits for both disabled and healthy populations. A pilot database defining the …
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DEM [Discrete Element Method] simulations of drained and undrained behaviour
… and liquefaction is shown to be related to structural mechanism. An attempt has been made to compare the axisymmetric compression and plane strain deformation for the drained and undrained conditions respectively. Shear strength criteria are examined and the Lade criterion is shown to be the …
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Shield and Shuttle: Importins as Protective Chaperones and the Nuclear Transport Mechanism of H2A-H2B
… discuss how I played a part in unraveling the structural mechanism of the evolutionary conserved H2A-H2B core recognition, chaperoning, and release by Kap114 and its human homolog Imp9. I will also expand upon another importin, Kapβ2, and its mechanism in preventing RNA binding protein FUS, a …
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Structural enzymology of soluble methane monooxygenase protein-protein interactions.
… (MMOR), and the regulatory protein (MMOB). The structural mechanism of how these sMMO components interact to regulate the formation and decay of the chemical intermediates of the reaction cycle is not well understood. Our recent advances in sMMOH expression and purification have allowed us to …
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Physical Studies of Actin Nucleation and Conformational Dynamics
… of filament subunits to free monomers. The structural mechanism through which nucleotide conveys information throughout the actin monomer to influence polymerization behavior remains poorly understood and represents a persistent fundamental biological question. In this work I, for the first …
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Structural and Functional Characterization of SPOA Domains in Salmonella Typhimurium Type III Secretion Systems
… of antimicrobial therapy. By understanding the mechanisms used by bacteria to manipulate their host and cause disease, it is hypothesized that we might more rationally approach anti-infective therapeutic design. Type III secretion systems (T3SS) are employed by some gram-negative human pathogens …
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The Gendered Effects of Marriage on Health in Japan: Structure, Role Expectations, and Outcomes
… gendered division of labor is an important structural mechanism that determines more work hours for married men, leading to different health consequences for men and women. While married women are expected to have a better health status by reducing their work hours following marriage, …
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Structural and Functional Studies of Mycobacterial General Transcription Factors RbpA and CarD
… tuberculosis (Mtb). In this thesis, I report the structural and biochemical characterization of RbpA and describe how it works synergistically with CarD to compensate for the unstable RNAPpromoter complexes formed in mycobacteria. I describe two crystal structures, Mtb …
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Multi-Modal Regualtion of Actin Networks
… crosslinking, but at the molecular level, the structural mechanisms by which different actin binding proteins bind, assemble, and regulate different actin networks remain largely elusive. It is also known that the actin cytoskeleton mediates mechanical coupling between eukaryotic cells and …
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Solid-state NMR spectroscopy applied to model membranes: effects of polyunsaturated fatty acids
… acid (DHA) is one of these n-3 PUFAs. As yet the structural mechanism responsible for the health benefits within the body is not completely understood. One model that has emerged from biochemical and imaging studies of cells suggests that n-3 PUFAs are taken up into phospholipids in the plasma …
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Characterization of swimming motility in a marine unicellular cyanobacterium
The structural mechanism, behavior, energetics and functional significance of the unique swimming motility displayed by some oceanic isolates of the cyanobacterium Synechococcus was investigated. A variety of analytical techniques confirmed that these strains swam through liquids without flagella …
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Cryo-EM Studies of Bacterial RNA Polymerase
… and a large cleft where the active site sits. Structural information about this essential enzyme has mainly been provided by X-ray crystal structures of stable transcription complexes. RNAP crystal structures are difficult to obtain and the captured states may not always represent physiological …