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Showing 1 to 4 of 4 for “"Structural Classification of Proteins (SCOP)"”.
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The early history and emergence of molecular functions and modular scale-free network behavior
The formation of protein structural domains requires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional loop (EFL) sequences and domain structures defined …
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Analysis of protein secondary structure via the discrete wavelet transform
… we convert the primary amino acid sequence of the protein to a numerical signal using the hydrophobic tendencies associated with the amino acids. The data used in this project consists of both a + B and a/B proteins coming from the Structural Classification of Proteins (SCOP) protein …
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Exploiting gene expression and protein data for predicting remote homology and tissue specificity
In this thesis I describe my investigations of applying machine learning methods to high throughput experimental and predicted biological data. The importance of such analysis as a means of making inferences about biological functions is widely acknowledged in the bioinformatics community. …
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A dynamic model for the evolution of protein structure
… domains are three-dimensional arrangements of atomic structure that are recurrent in the proteomes of organisms. Since the three-dimensional structure of a protein determines its function, it is the fold, much more than the underlying protein sequence and underlying chemistry, that is …