Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Structural Activity Relationship"”.
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Development of pharmacophore and comfa study of rigid and flexible sigma 2 receptor ligands
… to investigate a three dimensional quantitative structural activity relationship (3D-QSAR) model for 62 receptor ligands. Three CoMFA maps were developed to compare the electrostatic and steric properties of each calculation and molecule. The best CoMFA results were obtained by using a training …
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
… suggests that the compounds synthesized have activity as CCR5 antagonists and as anti-proliferative agents in certain prostate cancer cell lines. In addition, a bivalent ligand containing both a mu opioid receptor (MOR) and a CCR5 antagonist pharmacophore was designed and synthesized in order …
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Using Chemically Modified Oligonucleotides to Modulate Gene Expression, Treat Genetic Diseases, and Probe Novel Mechanisms of RNA Interference
… mutant HTT mRNA versus that of the wild-type. Structural-activity relationship (SAR) studies showed that several ss-siRNAs tolerated significant structural modifications and still retained high potency and selectivity. Furthermore, intraventricular infusion of a candidate ss-siRNA in a HD …
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Benzannulated indoles as drug discovery templates. Efforts towards the total synthesis of a library of therapeutic candidates inspired by Cis-Trikentrin A
… and trikentrin indole alkaloids are a series of structurally related natural products, characterized by a 6,7-benzannulated indole core – a structural motif rarely observed in nature. Originally isolated from the Trikentrion flabelliforme, and Axinella sp. sponges, these compounds present as …
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I. Stereochemical Control of Chiral Assembly and Liquid Crystal Phase Formation of Nonamphiphilic Molecules in Water II. Control Bacterial Quorum Sensing and Quorum Sensing-mediated Activities Using Small Unnatural Molecules
… inhibit biofilm formation. Primary studies of structural activity relationship revealed that the alkyl chain length was critical to activities of SHLs. These SHLs are promising candidates as modulators of other AHL-mediated QS systems.</p>
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The Synthesis of Amphiphilic Glycolipids as Potential Inhibitors of Bacterial Adhesion
… anti-adhesion agents in order to determine a structural activity relationship. The biological evaluation of selected glycolipids is discussed in chapter 5. Selected aspartic acid, aliphatic and aromatic glycolipids are investigated as potential inhibitors of Burkholderia multivorans adhesion …
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C-H Activation of Functional Materials
… enables the overriding of the natural reactivity of the 1, 3-position to conveniently access 2-arylated azulene, without regioselectivity issues and in moderate to high yields. The reaction was found to tolerate a wide range of aryl groups, including some heteroarenes. In-situ …
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Interpretation, Identification and Reuse of Models. Theory and algorithms with applications in predictive toxicology.
… are presented in the framework of Quantitative Structural-Activity Relationship (QSAR) models, but their application is much more general. QSAR models relate chemical structures with their biological, chemical or environmental activity. There are many applications that offer an environment to …
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Interpretation, Identification and Reuse of Models. Theory and algorithms with applications in predictive toxicology.
… are presented in the framework of Quantitative Structural-Activity Relationship (QSAR) models, but their application is much more general. QSAR models relate chemical structures with their biological, chemical or environmental activity. There are many applications that offer an environment to …
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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma
… carcinoma cell lines (HepG-2) significantly. Structural activity relationship studies suggested the potential of the 23, 24 enone side chain of CUCS to bind to the Epidermal Growth Factor Receptor (EGFR). Due to the limited quantities of CUCS upon isolation and the challenges of total …
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Understanding the Chemistries of Ni-rich Layered Oxide Materials for Applications in Lithium Batteries and Catalysis
… of materials is their inherent electronic and structural fragility. The fragility of these materials is facilitated by a cooperation of metal cation migration, lattice oxygen loss, and undesirable oxide cathode-electrolyte interfacial reactions. Each of these phenomena contribute to complex …