Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Stromal Remodeling"”.
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Host-intrinsic factors determine anti-tumor efficacy of exercise in pancreatic ductal adenocarcinoma
… immune cells.</p> <p>We interrogated tumor stromal composition changes with exercise and observed a gut microbiome dependent reduction in alpha smooth muscle actin (αSMA<sup>+</sup>) cells and <em>Il6</em> expressing inflammatory cancer associated fibroblasts (iCAFs). Similar analysis of …
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… molecules are involved in tumor progression, stromal remodeling, angiogenesis, and hormonal regulation. Results confirm that canine tumors can harbor multiple therapeutically relevant molecular targets. FAP and EDB+FN are promising targets for payload-delivery and immunocytokine therapies, …
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Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… minimal understanding around its wider impact on stromal remodeling and immunological activation. This study investigates the immunomodulatory effects of RFA combined with neoadjuvant chemotherapy in clinical samples and in combination with immune checkpoint blockade using a syngeneic pancreatic …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… Distally, chronic systemic inflammation and stromal remodeling distort the architectural integrity of secondary lymphoid organs. This systemic decay disrupts germinal center organization and impairs the priming of effector cells, effectively collapsing coordinated humoral and cellular …
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Insights into the role of hepatic stromal cells and the immune checkpoint protein PD-L1 in liver metastases of pancreatic cancer
… of human liver metastases revealed profound remodeling during progression. Large metastases (>1500µm) exhibited higher HMF abundance (αSMA) and proliferation (Ki67) than small lesions (≤1500µm). In small metastases, CD8+ T cells were evenly distributed, and PD-L1 was absent or central. …