Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 117 for “"Stromal Cell"”.
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Dietary regulation of myelopoiesis and stromal cell isolation
… chloride did not alter monocyte, granulocyte, T cell, B cell, or NK cell distributions in blood. In spleen, 10% sodium chloride did reduce the presence of NK cells but had minimal effect on other cell populations. In bone marrow, 10% sodium chloride increased the presence of T cells and both …
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Identification of molecular signaling pathways underlying human endometrial stromal cell differentiation
… the differentiation of endometrial stromal cells, is essential for a successful pregnancy. Although the steroid hormones estrogen (E) and progesterone (P) are known to control decidualization, the precise mechanisms via which these hormones act to control this differentiation process …
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Bone Marrow Stromal Cell Invasion and Bone Regeneration in Enzymatically-Degradable Osteoinductive Hydrogels
… In the first part, the effect of conjugation of cell adhesion RGD peptide and osteogenic peptide KIPKA SSVPT ELSAI STLYL to a model biodegradable hydrogel on osteogenic differentiation of BMS cells and production of mineralized matrix was studied. RGD peptide was grafted to the hydrogel by adding …
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Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… therapies available. Human Mesenchymal Stromal Cells (hMSCs) are a promising candidate therapy which are currently being investigated in clinical trials for ARDS. However their mechanisms of effects in lung injury are not fully elucidated. A fuller understanding of these mechanisms may …
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Toward understanding and mitigating heterogeneity in bone marrow stromal cell cultures for improved therapeutic efficacy
Bone marrow stromal cells (BMSCs), a subset of which are considered mesenchymal stem cells (MSCs), have been used in over 600 clinical trials for indications ranging anywhere from autism to liver cirrhosis to diabetes. They have cited enthusiasm in the cell therapy community not only for their …
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Investigation of efficacy and mechanisms of action in mesenchymal stromal cell therapy for chronic lung diseases
Mesenchymal Stromal Cells (MSC) are adult multipotent cells that possess self-‐renewal and regenerative capacities, with the ability to differentiate into a variety of cell types. They have potent immunosuppressive abilities, facilitating the use of allogeneic MSC as a cellular therapy. …
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Investigating the efficacy and mechanism of action of mesenchymal stromal cell therapy in burn wound healing
Several studies suggest that mesenchymal stromal cell (MSC) therapy may be efficacious in accelerating wound healing. Which source of MSC is therapeutically superior has not been well established, especially in large clinically relevant animal models. We therefore investigated the efficacy of Bone …
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An Investigation of The Effect of Hypoxic Culture on Mesenchymal Stromal Cell Immunomodulation and Biodistribution in-vivo
… the effects of hypoxic culture on mesenchymal stromal cell (MSC) immunomodulation and biodistribution in-vitro and in-vivo. Thus far, MSC have proved therapeutically beneficial for a number of inflammatory diseases such as acute Graft versus Host Disease (aGvHD). However, despite extensive …
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Stromal cell derived factor-1/CXCL12 acts as a hematopoietic progenitor cell survival factor by reducing apoptosis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Role of transcription factor Runx1 in uterine stromal cell differentiation and maternal-fetal interaction during mouse pregnancy
The differentiation of endometrial stromal cells to decidual cells, a process known as decidualization, is essential for the establishment of pregnancy. The decidual tissue produces multitude of factors that control a variety of physiological processes at the fetal-maternal interface, such as …
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Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
… the immune system is able to recognise cancer cells. It is unclear whether tumours escape this immune surveillance by selection of non-immunogenic variants in a Darwinian process termed cancer immunoediting, or by the recruitment of immune suppressive cells to the tumour microenvironment. This …
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Rational design to control multipotent stromal cell migration for applications in bone tissue engineering and injury repair
Multipotent stromal cells derived from bone marrow hold great potential for tissue engineering applications because of their ability to home to injury sites and to differentiate along mesodermal lineages to become osteocytes, chondrocytes, and adipocytes to aid in tissue repair and regeneration. …
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Tracing of Alpha-to-Beta Cell Transition Following Treatment with CHIR-Injected Human Multipotent Stromal Cell Secreted Proteins
… symptoms but cannot restore endogenous beta cell function. Regenerative strategies have demonstrated beta-cell neogenesis following ablation; however, the cellular mechanisms driving islet regeneration remain unclear. Previous work from the Hess Lab has shown that human bone marrow-derived …
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Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
… in human bone marrow-derived multipotent stromal cells (hMSC) generated conditioned media (CM) that promoted β-cell regeneration in streptozotocin-treated mice. Ductal-derived endocrine progenitors, which have been shown to generate β-cells following pancreatic injury, represent a …
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A Delineation of Mesenchymal Stromal Cell Therapeutic Action in New Models of Acute and Chronic Graft versus Host Disease
… potent immune regulatory capacity of mesenchymal stromal cells (MSC) has been extensively characterised in terms of T cells, natural killer cells and dendritic cells suppression; however the ability of MSC to modulate B cell biology is not fully understood. This immune suppressive ability has led …
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The effect of Stromal cell Derived Factor-1 (SDF-1) and collagen-GAG (Glycosaminoglycan) scaffold on skin wound healing
… also suggests that down-regulating inflammatory cells and up-regulating stem cells and progenitors cells would yield less scar formation. But, these therapies require an expensive isolation and culturing process from the patient's bone marrow. Additional risks include immune rejection concerns, …
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Effekt einer transendokardialen kathetergestützten Applikation von Stromal cell derived factor 1[alpha] auf die linksventrikuläre Funktion im Herzinfarktmodell im Schwein
… of catheter-based transendocardial delivery of stromal cell-derived factor 1 alpha on left ventricular function in a porcine model of myocardial infarction. In domestic pigs myocardial infarction was induced via microembolization of the distal left anterior descending artery. Catheter-based …
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