Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 261 for “"Stroma"”.
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Structural Studies of the Corneal Stroma
The corneal stroma is an unusual connective tissue in that it is transparent to visible light and that it can swell to many times its original weight when placed in salt solution with a consequent loss in transparency with swelling. The stroma consists of lamellae of parallel collagen fibrils, of …
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Rôle de PI3Kα dans la formation du stroma environnant
Nous avons étudié l’implication de la sous unité p110α dans la formation de la fibrose et des lésions du pancréas dans un contexte de pancréatite. L’équipe a déjà pu montrer que l’inactivation pharmacologique et génétique de la PI3Kα dans un modèle murin de PDAC (mutation KRas dans la lignée …
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Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology
1 in 9 men will be diagnosed with prostate cancer during their lifetime and it remains the second leading cause of cancer death among American men. Men who fail standard-of-care androgen deprivation therapy (ADT) and progress to metastatic castration resistant prostate cancer (mCRPC) are left with …
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Cellular and molecular immunotherapeutics derived from the bone marrow stroma
The bone marrow contains a multipotent stromal cell, commonly referred to as a mesenchymal stem cell (MSC). There has been recent interest in the clinical use of MSCs for cell-based therapy because: (1) bone marrow aspiration is a routine method used in medicine thereby allowing for easy …
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Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
Dense desmoplastic stroma is a fundamental characteristic of pancreatic ductal adenocarcinoma (PDAC) and comprises up to 80% of the tumor mass, which acts as a barrier that impedes the delivery of antitumor drugs into the tumor microenvironment and reduces the therapeutic efficacy. The objective of …
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The Biomechanical Role of Cancer-Associated Fibroblasts In Tumor-Stroma Reciprocity
… environment surrounding tumors, the tumor stroma, and investigates what effects the components within the stroma have on tumorigenesis. In addition, which components of the extracellular matrix contribute to that stiffening and how those components contribute to tumorigenesis will also be …
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Dissecting the interplay between cytotoxic T lymphocytes and the pancreatic cancer stroma
… characterised by a particularly dense fibrotic stroma shaped predominantly by cancer-associated fibroblasts (CAFs), which restrict T cell access and undermine immunotherapeutic efficacy. To better understand how this stromal architecture shapes CTL behaviour, we developed an in vitro organotypic …
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Bone Marrow Derived Progenitor Cells and Their Contributions to the Thymic Stroma
… that contribute to the maintenance of the thymic stroma. Immunofluorescence microscopy of FACS sorted CD45+ EpCAM+ cells from thymus and bone marrow confirmed surface protein expression of both markers, while Q-rtPCR confirmed co-expression of both genes at the RNA level. CD45+ EpCAM+ cells sorted …
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Engineered models of the lymphatic stroma to study cell and fluid transport
… tissue-specific engineered models of the LN stroma and the meningeal lymphatics to examine the transport of cells and fluid. Within the LN, fibroblastic reticular cells (FRCs) maintain a network of extracellular matrix conduits that guide varying rates of interstitial fluid flow (IFF) based …
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The Role of Interferon Gamma in the Stroma of Growing and Regressing Tumours
Das Ziel dieser Arbeit bestand in der Identifizierung des Ursprunges und der Charakterisierung der Rolle von Interferon gamma (IFNg) in der Abstoßung von Tumoren durch geringe Konzentrationen von Cyclophosphamide (Cy). Diese Arbeit zeigt, daß haematopoetische Zellen IFN-g produzieren, welches für …
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Lymph node and peri-lymph node stroma : phenotype and interaction with T-cells
The non-hematopoietic, stationary stromal cells located inside and surrounding skin-draining lymph nodes play a key role in regulating immune responses. We studied distinct populations of lymph node stromal cells from both human subjects and animal models in order to describe their phenotype and …
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Cll Metabolism Is Regulated By Prognostic Factors, Modulated By Stroma and Abrogated By Pi3K Inhibition
… B cells has been little explored. Bone marrow stromal cells provide a survival benefit to CLL cells, in part through PI3K/AKT pathway. Compared with proliferative B-cell lines, metabolic fluxes of oxygen and lactate were low in quiescent malignant B lymphocytes from CLL patients. Glycolysis …
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Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma
… epithelial tissues and a desmoplastic stroma formed by accumulation of hematopoietic cells, mesenchymal stromal cells and extracellular matrix. The crosstalk between malignant epithelial cells and tumor stroma is becoming increasingly appreciated as a key determinant in tumor …
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Development of Microfluidic 3D Cell Array with Tumor-Stroma interaction for Cancer Immunotherapy Drug Screening
… associated fibroblasts (CAFs), the most abundant stromal cells in TME, were encapsulated with cancer cells in Matrigel to reconstruct TME that is more physiologically relevant. Compared with conventional 2D in vitro assays, in our platform, the spatial configuration of endothelial monolayer on the …
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The Effect of Dietary Fat on The Stroma Lipids and Properties of The Rat Erythrocyte
Made available in DSpace on 2014-12-05T19:06:53Z (GMT). No. of bitstreams: 1 6305156.pdf: 4355966 bytes, checksum: 651453b33b88fa5ef5288e4afc6997be (MD5) Previous issue date: 1963
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
Kidney cancer is the 14th most common cancers in the world, among which clear cell renal cell carcinoma (ccRCC) is the most common subtype. VHL inactivation is the most common mutation seen in ccRCC with more than 90% of tumours had clonal disruption of the VHL pathway. Although it is the initial …
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Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration
… in the osteogenic potential of the bone marrow stroma following glucocorticoid treatment, Sprague-Dawley rats were administered methylprednisolone for up to six weeks, then sacrificed at 0, 2, 4, or 6 weeks during treatment or 4 weeks after cessation of treatment. Femurs were collected and …
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Defining the clinical importance of epithelial-stroma-immune signalling in colorectal cancer using a molecular pathology approach
… transition (EMT) signalling and an abundance of stroma (particularly fibroblasts) in their tumour microenvironment. To date, there has been inconsistent data regarding the benefit of standard chemotherapy in these patients with high-fibroblast (HiFi) tumours. Additionally, there is limited …
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