Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 192 for “"Striatal"”.
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Striatal Dopamine Dynamics Upon Manganese Accumulation
<p>STRIATAL DOPAMINE DYNAMICS UPON MANGANESE ACCUMULATION </p> <p>by MADIHA KHALID</p> <p>August 2013</p> <p>Advisor: Dr. Tiffany Mathews</p> <p>Major: Chemistry (Analytical)</p> <p>Degree: Doctor of Philosophy</p> <p>Although manganese (Mn) is fundamental for many biological processes, exposure to …
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Striatal Microcircuits Underlying Control of Actions
… striatum and movement, the mechanism of how striatal activity in the dorsal striatum contributes to movement velocity remains unclear. One reason is that traditional experimental designs of the basal ganglia have either considered actions as discrete events or neglected to measure movements …
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Enhanced striatal glutamatergic function upon chronic antipsychotic action
… clozapine. Furthermore, we find that striatal astrocytes also respond to chronic antipsychotic treatment with translational alterations promoting synaptogenesis. Together, these data have identified a core molecular signature of increased glutamatergic transmission in the striatum …
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The Neurotoxicity of Insecticides to Striatal Dopaminergic Pathway
… classes of insecticides/drugs/neurotoxins to the striatal dopaminergic pathway and their potential relationship to Parkinsonism in the C57BL/6 mouse model, using biochemical and molecular biology methods. In the first objective, I investigated the neurotoxicity in striatal dopaminergic pathways …
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Compensation Between Foxp Transcription Factors Maintains Proper Striatal Function
… Foxp2 where one transcription factor maintains striatal function upon the loss of the other, which I discuss more in depth (Chapter Eight). I also discuss my involvement in a project where we further study the role of Foxp1 in D1- and D2-SPNs, which I am working on in collaboration with Dr. …
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The role of frontal-striatal circuits in instrumental behaviour
Behaviour can be goal-directed, when performing an action to obtain a specific goal, and it can be habitual, whereby a stimulus in the environment can trigger a response regardless of the outcome. Behavioural output can be a mixture of goal-directed and habitual aspects and there may be a …
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Dopamine-dependent Transcriptional Dynamics in Striatal Physiology and Cocaine Reward
… tools both in vitro and in vivo, we showed that striatal Gadd45b expression is induced upregulated by dopamine and affects striatal physiology. Additionally, we demonstrate that Gadd45b is necessary for dopamine-dependent DNA methylation dynamics and cocaine reward memory. Overall, these data …
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Cerebello-striatal connectivity and implicit learning in autism spectrum disorders
Previous studies have indicated that persons with autism spectrum disorder have distinct cerebella, striatum, and an impaired ability to anticipate implicit learning sequences; also, previous research indicates anatomic connections among these regions. Investigating distinctions in connectivity and …
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Excitatory synaptic transmissions in striatal neurons after transient global ischemia
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Neonatal striatal dopamine denervation: consequences of P0 and P7 lesions
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Anatomical and Physiological Characterization of Striatal Activation of the Cerebral Cortex
… striatum is important. The monosynaptic corticostriatal cir-cuit has been extensively studied. In contrast, due to the poly-synaptic nature of the connec-tions between the striatum and the cortex, how the striatum and striatal dopaminergic activi-ty each influences or feedbacks the cerebral …
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Striatal Dopamine Release by Serotonergic Terminals in the Dopamine-Depleted Rat
… to DA is not well understood. Three likely striatal sites meeting the requirement of amino acid decarboxylase presence include remaining dopaminergic neurons, serotonergic terminals, and striatal intemeurons.</p> <p>Studies have shown that serotonin (5-HT) neurons are capable of DA synthesis …
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Estradiol Has Distinct Effects on the Hippocampal and Striatal Memory Systems
… altering the responsiveness of hippocampal and striatal cells to experience, estradiol biases the type of information obtained, resulting in enhanced or impaired learning depending on the task variables.
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Compartmental organization in embryonic striatal grafts and in the developing striatum
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1991.
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COGNITIVE DECLINE WITH AGE: ROLE OF STRIATAL CHOLINERGIC SYSTEM AND GROWTH HORMONE
… on hippocampal/mediotemporal lobe and frontostriatal function, brain regions involved in memory and behavioral flexibility, respectively, and to investigate potential factors associated with cognitive decline.
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