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Showing 1 to 11 of 11 for “"Stretch injury"”.
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Multi well uni-axial stretch injury device
Most diffuse brain injury is the result of uni-axial stretch of brain axons in traumatic brain injury. Traumatic injury to axons throughout the brain and is believed to be a major cause for coma, and other complications. Diffuse axonal injury is mostly multi-focal and appears throughout the deep …
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The effects of rapid stretch injury on rat neocortical cultures
Several key biological mechanisms of traumatic injury to axons have been elucidated using in vitro stretch injury models. These models, however, are based on the experimentation of single cultures keeping productivity slow. Indeed, low yield has hindered important and well founded investigations …
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Stretch Injury Alters Calcium Dynamics and Actin Organization in Human Astrocytes
Traumatic brain injury (TBI) is a major public health concern, linked to long-term neurodegenerative conditions such as Alzheimer’s disease. Although neurons are often the primary focus of TBI research, growing evidence highlights the critical role of astrocytes—especially their calcium signaling …
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An in vitro study to characterize a new automated high throughput neuronal stretch injury system
Traumatic brain injury (TBI) is one of the most prevalent long-term neurological conditions and its overall economic consequences rival that of stroke. Considering the importance of the topic, new models for studying TBI are often designed and created. Based on a model developed by the University …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
… diseases and after traumatic brain injury (TBI). In this work, I aimed to study TBI-induced dysregulation of neurogenesis and to assess the therapeutic potential of a highly innovative non-invasive device, combining the benefits of both near infrared laser light (808nm) and …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
… diseases and after traumatic brain injury (TBI). In this work, I aimed to study TBI-induced dysregulation of neurogenesis and to assess the therapeutic potential of a highly innovative non-invasive device, combining the benefits of both near infrared laser light (808nm) and …
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Diffuse axonal injury effect on myelinating cells and axons
… whether myelin degeneration in diffuse axonal injury (DAI) of the white matter is due to death of myelinating oligodendrocytes or secondary axotomy. Cortical neurons are not able to remain healthy in culture to have their axons myelinated. Dorsal root ganglion (DRG) neurons have been shown to …
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Experimental Modelling and Molecular Mechanisms of Wallerian Degeneration in Traumatic Axonal Injury
Traumatic brain injury (TBI) is a common event that can lead to profound consequences for the individual involved, and a considerable socio-economic cost. The initial injury event triggers a series of secondary brain injury mechanisms that lead to further mortality and contribute to morbidity. One …
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Response of stretch-injured schwann cells
… have been performed to observe and analyze stretch injured axons, but very little has been done to study the white matter axonal tracts, oligodendrocytes. Schwann cells can help take a first look into stretch injured glia cells from the Peripheral nervous system. In order to observe changes …
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Localizing Strain in a 2D in vitro Stretch System to Model Regional Injury Dynamics
Traumatic brain injury (TBI) is a disruption in normal brain function caused by mechanical insult to the head. Nonuniform brain tissue deformation complicates TBI diagnosis and treatment. Capturing this spatial heterogeneity in vitro is important for studying region-specific injury responses under …
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Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
… yet unsolved quest in treating traumatic brain injury (TBI) is the understanding of the secondary cellular injury that contributes to cell death. Whether zinc ions are toxic or protective in TBI is controversial. As an essential human micronutrient, zinc is needed for the structure and function …