Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Stress-response protein"”.
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The localization, function and applications of the stress response protein Hsp12p in the yeast Saccharomyces cerevisiae
… yeast Saccharomyces cerevisiae small heat shock protein Hsp12p, has continuously appeared in data associated with stress responses in this organism. Hsp12p is expressed abundantly in response to a large variety of different stresses, but for many years has eluded researchers as to its function, …
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The functional significance of Hsp12p and trehalose in desiccation and oxidative stress in the budding yeast Saccharomyces cerevisiae
… utilise this technology. The significance of the stress response protein and putative hydrophilin, Hsp 12p, was therefore examined in vivo under desiccation conditions.
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Investigating The Dysregulation And Therapeutic Potential Of Neuroprotective Stress Response Proteins In Huntington’s Disease
… is protective in HD models. RNA binding motif protein 3 (RBM3) is a stress response protein that promotes synaptic plasticity and cell survival, and is dysregulated in Alzheimer, prion and HD models. Hippocampal overexpression of RBM3 in Alzheimer and prion murine models is neuroprotective and …
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The isolation and characterization of heat shock protein Hsp12 in Lipomyces starkeyi
The stress response protein Hsp 12 is induced in S. cerevisiae cells upon exposure to salt stress, heat shock, ethanol, and upon entry to stationary phase (Mtwisha et aI., 1998). In this study, the occurrence of proteins related to Hsp12 was investigated in a number of yeasts (namely, Saccharomyces …
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The Effect of Early Dietary Intervention on Alzheimer's Disease-Related Pathology and Cognitive Function in Mice
… disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits, neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss. AD is a multifactorial disease, and lifestyle factors, including diet, are likely associated with the development of AD pathology. Since …
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Contribution of LEDGF/p75 to Prostate Cancer Chemoresistance
… pathways. We also investigated the role of the stress response protein and transcription co-activator lens epithelium derived growth factor p75 (LEDGF/p75) in HRPC resistance to DTX. Our studies show that LEDGF/p75 overexpression attenuates DTX-induced lysosomal destabilization and cell death in …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
… prostate inflammation resulting in activation of stress and prosurvival pathways contribute to disease progression and the development of chemoresistance. Lens epithelium-derived growth factor p75 (LEDGF/p75) is a stressresponse protein that promotes cellular survival against environmental …
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Rapid Alterations in Rat Brain Tryptophan Hydroxylase Activity; Effects of Adrenal Steroids, Drugs and Stressors
… This increase was blocked by cycloheximide, a protein synthesis inhibitor. The midbrain enzyme activity was increased in normal rats by short term stressors--cold (5° C), ether, and electric foot-shock--which resulted in increase plasma corticosterone levels. Adrenalectomized rats showed no …
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Structural and Functional Studies of the Unconventional Proteobacterial Transcription Activator Crl in Complex with the Transcription Machinery
… RNA polymerase (RNAP) is the master regulator of stress responses in many Gram-negative bacteria. This alternative σ factor assembles with the core RNA polymerase to initiate the transcription of genes needed to survive different environmental changes. Crl is a small protein that activates the …
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Circadian Regulation of Protein Homeostasis
… processes. In various models, rhythms in protein abundance of 10-20% of the proteome have been reported. However, regulation of these rhythms is not well understood, as most of them are not accounted for at the transcript or even ribosomal occupancy level. It is also unclear how circadian …