Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Stress signalling"”.
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Characterization of the degradation of wild-type and mutant HFE proteins during stress signalling in the endoplasmic reticulum
… and explored their regulation during ER stress conditions.
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Regulation of the anti-senescence factor, TBX2, by the UV stress signalling pathway and the mitotic cyclin dependent kinases
… and cancer. This study shows that the p38 stress mitogen-activated protein kinase, and the mitotic cyclin A/Cdk2 and cyclin B1/Cdk1, are direct regulators of Tbx2 both in vitro and in vivo. It is possible that Tbx2 and Tbx3 may contribute towards the oncogenic process through their …
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Effects of Chronic Oxidative Stress on TRPM2 and TRPC3 Channels: Potential Implications for Bipolar Disorder
Intracellular calcium and oxidative stress dyshomeostasis, which can be highly interactive, occur in bipolar disorder (BD), but the pathogenesis of these disturbances is unknown. The transient receptor potential (TRP) melastatin subtype 2 (TRPM2) and canonical subtype 3 (TRPC3) calcium-permeable …
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New signalling network in plant abiotic stress discovered through a genetic approach
… mutants deregulated in the response to abiotic stresses has been isolated using an EMS-mutagenised population carrying the luciferase cDNA under the control of the RCI2A promoter. RCI2A gene is expressed after exposure to low temperatures, dehydration, high salinity, and the ectopic application …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… disease imperative. Endoplasmic reticulum (ER) stress has emerged as a potential mechanism driving the pathogenesis of obesity and T2DM. Palmitate, the predominant saturated fatty acid elevated in the blood plasma of obese individuals, induces ER stress and insulin resistance in skeletal muscle. …
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Investigating the biological roles of the HSPRO genes in Arabidopsis thaliana
… and responses to diverse environmental stresses. Stress can be the result of both biotic and abiotic agents and the ORTHOLOG OF SUGAR BEET HS1 PRO-1 (HSPRO 1) and HSPRO2 genes were previously shown to be induced in response to several stresses including infection with Pseudomonas …
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Epitranscriptional Control of the Caspase-2—MDM2—p53 Axis: The Role of the m6A Writer in p53 Signaling.
… the proteolytic events driving this stress signalling response, the contribution of RNA-based regulatory layers has remained largely unexplored. This study identifies an unexpected role for N6-methyladenosine (m6A) RNA methylation as an essential post-transcriptional determinant of …
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INTEGRATED TRANSCRIPTOMIC AND TRANSLATIONAL PROFILING OF EIF6-SBDS IN SHWACHMAN-DIAMOND SYNDROM REVEALS DIFFERENT CELLULAR STATES SHAPED BY RIBOSOME COMPOSITION AND FIDELITY
… translational output, decoding fidelity, and stress-response pathways. Additional analyses of rRNA fragments, snoRNA dynamics, and inferred ribosomal-protein association provided complementary insight into consequences on ribosome assembly. Translation assays showed that both SBDS depletion …
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NAC transcription factors in sugarcane and their functional role in drought tolerance
… due to the complex, polygenic nature of abiotic stress responses, highlighting the importance of identifying single regulatory elements capable of modulating multiple stress response pathways. NAC (No apical meristem [NAM], Arabidopsis transcription activation factor [ATAF], Cup-shaped cotyledon …
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Phosphate starvation alters calcium signalling in roots of Arabidopsis thaliana
… is known to signal in plant development and stress perception, and most recently its direct role in signalling nutrient availability and deficiency has been partially elucidated. The use of Ca2+ as a signal has to be tightly controlled, as Ca2+ easily complexes with P groups and therefore is …
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The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
… with antibodies against key protein markers of stress signalling, cell cycle, apoptosis and autophagy. The results indicated that BTC2 activated the p38 MAP kinase signalling pathway and the p53 response in MCF7 cells. It is worth noting that MDA-MB-231 cells have a mutant p53 but that the p53 …
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Localisation and function of phosphoinositide-specific phospholipase C in Sacchromyces cerevisiae
… Ins(1,4,5)P\(_3\) in this fungi in response to stress and yet the yeast genome encodes no Ins(1,4,5)P\(_3\) receptor. This suggests that the functions of PLC-\(\delta\)s are mediated in a novel fashion, probably occurs via the higher inositol phosphates that derived upon rapid phosphorylation of …
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Structure and Mechanism of Hormone Perception and Signal Transduction by Abscisic Acid Receptors
… is a vital plant hormone that confers abiotic stress tolerance. ABA acts through inhibition of certain members of the type 2C protein phosphatase (PP2C), resulting in activation of the SNF1-related kinases (SnRKs) that positively transduce the ABA signal. The identity of ABA receptors had been …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
… with pro-survival, neuroprotective and anti-stress signalling functions. Autosomal recessive mutations in PINK1, resulting in a loss of PINK1 function, cause early onset Parkinson’s disease (PD). This thesis aimed to investigate the mechanisms by which PINK1 protects against PD, with a focus …
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Analisi integrata dell'espressione di geni/microrna in un modello di epatocancerogenesi sperimentale
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, accounting for an estimated half million deaths annually, and represents one of the major health problems. Although much is known about the cellular changes that lead to HCC, the molecular pathogenesis of HCC is not yet …