Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Stress signaling"”.
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Endogenous Stress Signaling within Human Multicellular Aggregates (Spheroids)
… and IL-8, thereby propagating the cellular stress signal within cells as well as throughout the aggregate. Cytokines exist <i>in vivo</i> as mixtures, yet tissue culture studies delineating how cells respond to these molecules are often performed using individual effectors added exogenously. …
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ROLE FOR HYDROGEN PEROXIDE DURING ABIOTIC AND BIOTIC STRESS SIGNALING IN PLANTS
… growth, development and yield. Common for such stress conditions is that they induce the accumulation of harmful reactive oxygen species (ROS). ROS, such as hydrogen peroxide (H2O2), are now also considered to be important signal molecules that regulate the defense response of plants to stress. …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… of caveolae in ROS/RNS generation and downstream signaling roles in activating endothelial cells are not well known. Hypothesis: Caveolae act as, a) micro-environments in providing spatio-temporal reaction compartments for ROS/RNS generation, tyrosine nitration of proteins, b) platforms to …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… Leucine Zipper Kinase (DLK) modulates neuronal stress responses, including neuronal loss implicated in various neurodegenerative conditions. DLK is axonally expressed and is under constant suppression under normal conditions. Although DLK is known to localize in axons and has crucial roles, the …
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Regulation of the anti-senescence factor, TBX2, by the UV stress signaling pathway and the mitotic cyclin dependent kinases
… and cancer. This study shows that the p38 stress mitogen-activated protein kinase, and the mitotic cyclin A/Cdk2 and cyclin B1/Cdk1, are direct regulators of Tbx2 both in vitro and in vivo. It is possible that Tbx2 and Tbx3 may contribute towards the oncogenic process through their …
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The role of the BHLH038 transcription factor in the regulation of osmotic and drought stress responses in Arabidopsis thaliana
The most important abiotic stress affecting agriculture worldwide is drought. In order to ensure food supply for the expanding world population two critical tasks must be undertaken; maintenance of crop yield as well as the increase of yield potential. Plants have built up a complex stress response …
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An Analysis of the Arabidopsis Aquaporin TIP1;1 and Analysis of Stress Response Signaling in Arabidopsis
The stress response pathways in Arabidopsis were studied, using publically available Affymetrix ATH1 microarray data. The salt stress signaling pathways were dissected, by comparing the salt stress response to other abiotic/biotic stress responses or the response to plant hormones. The analysis, …
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
… KDM inhibitor JIB-04, many genes in the ER stress signaling pathways were upregulated in SCLC cell lines, suggesting that this is the mechanistic path leading to SCLC death following Jumonji inhibition. Additional analysis revealed that JIB-04-resistant cells also activated pro-survival …
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Adenylyl Cyclase Type 9: Regulation and Cardiac Function
<p>Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction and relaxation under stress. Sympathetic …
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Connections Between Inositol Phosphate Signaling and Energy Responses in Plants
… for this is the inositol phosphate (InsP) signaling pathway. This work focuses on the role of InsP signaling in maintaining energy homeostasis in the plant. InsP signaling is connected to energy sensing in plants via a protein complex containing both the inositol polyphosphate …
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Specificity and structural characterization of the PDZ domain from DegS, an extracytoplasmic E. coli protease
… that is involved in the extracytoplasmic-stress response. The C-terminal domain has limited homology to PDZ domains and was thought to be involved in regulation or substrate recognition. A model of this PDZ domain was generated from NMR solution studies and homology modeling. Peptide …
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Trabecular Calcium Phosphate Scaffolds for Bone Regeneration
… models.The specific role of environment on cell stress pathways was evaluated on three dimensional (3-D) calcium phosphate scaffolds resembling vertebral trabecular bone. A scaffold foam dipping technique was employed in the fabrication of fully sintered hydroxyapatite and tricalcium phosphate …
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The Role Of The DOMAIN OF UNKNOWN FUNCTION (DUF2358) In Sugar Signalling Pathways In Arabidopsis thaliana
… also play a critical role in response to abiotic stresses such as drought and high salinity . This study was conducted to investigate the role of DUF2358 in sugar signalling pathways under stress conditions which affect primary metabolism. For that, we investigated the role of DUF2358 in stress …
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C. elegans integrates food, stress, and hunger signals to coordinate motor activity
… the roles of biogenic amines, metabolic, and stress signaling pathways on this behavior. We correlated specific sensory defects and the expression patterns of genes involved in sensory function, gathered by the community of C. elegans researchers, with abnormal responses to a bacterial food …
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Staphylococcus aureus virulence factors dictate host signaling pathways and immune responses
… for VF on PMN responses, so next we determined signaling pathways and cytokine responses of PMN to S. aureus toxins. Live S. aureus infections increased activation of stress signaling pathways and highlighted a role for agr-regulated genes in MAPK p38 phosphorylation and α-hemolysin in ERK …
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Genetic analysis of the neuronal integrated stress response in developmental plasticity and organismal physiology of C. elegans
… through evolutionarily conserved neuroendocrine signaling mechanisms. My genetic characterization of the previously isolated daf-28(sa191) mutant that enters dauer constitutively has revealed cell-nonautonomous roles of conserved stress signaling pathways-the Unfolded Protein Response (UPR) and …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… would inhibit endothelial mediated shear stress signaling and subsequently, the microvascular remodeling responses to prazosin administration. Lastly, CORT mediated hypertension and microcirculatory rarefaction would be prevented with 2 weeks of concurrent prazosin or Tempol (a ROS …
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Phosphatase Regulation of Mechanical Stress and Aging in C. elegans
Stress and aging embody two related processes driving cellular dysfunction. In either case, environmental stimuli and genetically encoded regulatory mechanisms affect cellular homeostasis and influence adaptation. Phosphatases represent master regulators of stress signaling and modulate cellular …
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Npsd4: A New Player In Sumo-Dependent Dna Repair
… under constant threat from sources of damage and stress. Improper resolution of DNA damage lesions can lead to mutations, oncogene activation, and genomic instability. Difficult-to-replicate-loci present barriers to DNA replication that, when not properly resolved, lead to replication fork …
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Distant chaperones and N-glycan signals : new mechanisms of secretory pathway proteostasis
… development, cells encounter physiological ER stress incurred by high levels of sustained protein production. Unresolved protein misfolding, on the other hand, results in pathological ER stress and tissue dysfunction. Prior work has used small model substrates to show that cells utilize …
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