Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Stress induced senescence"”.
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A Tissue-Engineered Blood Vessel Model for Vascular Aging
… atherosclerosis. In particular, endothelial cell senescence is implicated in age-related changes in vasoreactivity. Oxidative stress is considered the primary source of endothelial cell (EC) senescence in vivo. EC senescence leads to abnormal proliferation of vascular smooth muscle cells, reduced …
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Breeding broccoli resilient to multi-abiotic stresses using genome editing
Broccoli cultivars are sensitive to environmental stresses. Dramatic fluctuation in temperature and other weather conditions caused by climate change has negatively affected the growth and development of broccoli and reduced broccoli productivity and quality. Plant senescence is one of the most …
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Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage
… NAD+ stores and fuel resistance to oxidative stress. I established that oxidative-stress insult on vascular cells decreased NAD+ levels, accompanied by a striking increase in nuclear PAR-chain accumulation. PARP inhibition abolished PAR-chain formation and preserved NAD+ levels, establishing …
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Regulatio of actin cytoskeleton by TIS21 vi downregulating reactive oxygen species (ROS) in the doxorubicin-induced premature senescenc
… differentiation and apoptosis. Cellular senescence is an irreversible arrest of proliferation, which is induced by replicative cell division (replicative senescence) or stress (stress induced premature senescence; SIPS). Cellular senescence is induced by DNA damage, telomere shortening or …
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Regulation of the anti-senescence factor, TBX2, by the UV stress signaling pathway and the mitotic cyclin dependent kinases
… T-box factors, Tbx2 and Tbx3, can suppress senescence through repressing the cyclin dependent kinase inhibitors, p21wAF11 c1 P118011 and p19ARF. Both Tbx2 and Tbx3 have also been linked to several cancers primarily because their expression levels have been found to be deregulated in these …
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Regulation of the anti-senescence factor, TBX2, by the UV stress signalling pathway and the mitotic cyclin dependent kinases
… T-box factors, Tbx2 and Tbx3, can suppress senescence through repressing the cyclin dependent kinase inhibitors, p21wAF11 c1P118011 and p19ARF. Both Tbx2 and Tbx3 have also been linked to several cancers primarily because their expression levels have been found to be deregulated in these …
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Unraveling the ORE1 regulon in Arabidopsis thaliana : molecular and functional characterization of up- and down-stream components
Leaf senescence is an active process required for plant survival, and it is flexibly controlled, allowing plant adaptation to environmental conditions. Although senescence is largely an age-dependent process, it can be triggered by environmental signals and stresses. Leaf senescence coordinates the …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
Cellular senescence plays an important role in biological processes such as development, aging and tumorigenesis, and it is a process of permanent growth arrest when cells lose ability to reactivate cell division cycle. One of the common molecular features of senescent cells is the failure of …
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Investigation of a pancreatic derived progenitor cell population for use in regenerative medicine
… or as a direct in vivo cell therapy. Cellular senescence is a state of irreversible growth arrest that can be induced by multiple factors, including telomere dysfunction associated with replication and oxidant stress. Senescence of stem cell, or progenitor, populations has been proposed as a …