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Showing 1 to 8 of 8 for “"Streptomyces griseus"”.
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The effects of the three soil-inhabiting fungi on peanuts grown under germ-free conditions
… and in all combinations with Aspergillus flavus, Streptomyces griseus, and Trichoderma sp. All 3 organisms invaded the root tissue. When compared with uninoculated check plants, S. griseus individually caused no measurable damage, but in combination caused stunting and chlorosis. A flavus and …
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The Use of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities
… macrotetrolide antibiotic that is produced by Streptomyces griseus ETH A7796, is an ideal candidate for the synthesis of new antimicrobial drugs. This secondary metabolite is composed of two units of (+)-nonactic acid 49 and two units of (-)-nonactic acid 50. Whereas nonactin does not possess a …
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The Use of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities
… macrotetrolide antibiotic that is produced by Streptomyces griseus ETH A7796, is an ideal candidate for the synthesis of new antimicrobial drugs. This secondary metabolite is composed of two units of (+)-nonactic acid 49 and two units of (-)-nonactic acid 50. Whereas nonactin does not possess a …
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Discovering novel natural products from bioactive plants and bacteria
… As proof of concept, one cryptic pathway from Streptomyces griseus, containing a PKS/NRPS hybrid gene, was chosen as a model system. To decipher this cluster, I have been attempting to develop a new strategy based on our recently developed “DNA assembler” method. By using this approach, the …
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Two Methodologies in Pursuit of the Elucidation of Copper (II)—Centered Bioinorganic Chemistry
… method explored involves the promiscuous enzyme Streptomyces griseus aminopeptidase (SgAP) which although known primarily as a peptidase has been shown to oxidize catechol under near physiological conditions in vitro when its native ZnII ions are replaced by CuII ions. Protein engineering …
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Screening rare filamentous actinobacteria for novel antimycobacterial compounds
… and streptomycin originally isolated from Streptomyces griseus. Both these bacteria belong to the phylum Actinobacteria. Due to this history, filamentous actinobacteria were selected for screening of novel antimycobacterial compounds. However, the focus in this investigation was on species …
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Development and application of synthetic biology tools for natural product research
… Previously Zhao group discovered a PTM from Streptomyces griseus and characterized its biosynthesis, indicating a parallel biosynthetic mechanism. To further explore if this is general for the biosynthesis of all PTMs, I made four constructs which are supposed to make different intermediates …