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Showing 1 to 20 of 68 for “"Streptococcus pyogenes"”.
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Faraldsfræði Streptococcus pyogenes á Íslandi 2019-2024
Streptococcus pyogenes er einn af helstu sýkingarvöldum í mönnum og getur valdið misalvarlegum sýkingum. Í alvarlegustu sýkingunum er dánartíðnin almennt há. Bakterían býr yfir ýmsum meinvirkniþáttum sem hún nýtir sér til að komast hjá eða mæta vörnum hýsils og er M próteinið einn af mikilvægustu …
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Streptococcus pyogenes - a manipulator of human defences
Streptococcus pyogenes is a major human pathogen with more than 500 000 casualties annually of which at least 163 000 are due to invasive infections. The remainder is due to post-streptococcal complications with rheu¬matic heart disease constituting the majority. S. pyogenes also causes milder …
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On the induction of inflammatory reactions by Streptococcus pyogenes
Streptococcus pyogenes is an important human pathogen that causes significant morbidity and mortality worldwide. In order to successfully infect the human host, S. pyogenes is equipped with tools that modulate the human immune defence. The present thesis explores how different streptococcal …
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Platelets and their immunomodulatory roles during Streptococcus pyogenes infection
… cause of human disease and death worldwide. Streptococcus pyogenes is one of the major pathogens responsible for bacterial infections, which range from mild to severe and life threatening conditions. S. pyogenes contains a cell wall anchored M protein, which is an important virulence factor …
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Transcriptional Regulation of the MGA Virulence Regulon in Streptococcus Pyogenes
The group A streptococcus (GAS) is a strict human pathogen that is capable of causing an array of diseases ranging from pharyngitis (strep throat) to necrotizing faciitis (flesh-eating disease). The GAS possesses a transcriptional regulator called Mga, or the multiple gene regulator of the GAS, …
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Rgg2/Rgg3 Quorum Sensing in Streptococcus pyogenes and Innate Immune Cell Responses
… macrophages, a type of innate immune cell, and Streptococcus pyogenes, an important human pathogen. In Chapter 2 of this thesis, it is shown that physiologically relevant concentrations of nitric oxide generates dinitrosyliron complexes which deplete the available intracellular iron in S. …
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The Convergence of Metabolism and Virulence Factor Regulation on Streptococcus pyogenes Pathogenesis
… pathogenesis. For many pathogens such as <italic>Streptococcus pyogenes</italic>, the coordination of metabolism with the expression of virulence factors is necessary for colonization. Previous research examining the regulation of virulence factors in <italic>S. pyogenes</italic> identified a …
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The Role of Lysogenic Bacteriophage in Virulence and Survival of Streptococcus Pyogenes
… the interactions of lysogenic bacteriophage with Streptococcus pyogenes. We were specifically interested in elucidating novel ways in which the prophage influence GrAS virulence and survival either within the host cell or within the bacterial population. In turn, we also hoped to determine how the …
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Hyaluronate Lyase Gene of <i>Streptococcus pyogenes</i>: Molecular Characterization and Regulation
<p><em>Streptococcus pyogenes</em> causes an assortment of diseases ranging from pharyngitis to necrotizing fasciitis. This bacterium has the ability to elaborate several extracellular products capable of causing tissue damage; one of which is a hyaluronate lyase. Little information is available …
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Analysis of the molecular interplay between Streptococcus pyogenes and its human host
The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. …
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Identification of surface protein complexes of Streptococcus pyogenes through protein microarray technology
… this study approximately 100 proteins of Group A Streptococcus (GAS) predicted to be secreted or surface exposed by genomic and proteomic approaches were purified in a His-tagged form and used to generate protein microarrays on nitrocellulose-coated slides. To identify protein-protein interactions …
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The Dynamic Streptococcus Pyogenes Transcriptome in the Host Cell Environment and Contributions by Phage
… investigates the transcriptional responses of Streptococcus pyogenes in the pharyngeal environment and characterizes two transcriptional regulators involved in the adaptive response to the host. Furthermore, this thesis explores the potential role of integrated prophage on the streptococcal …
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Serotype Association and Regulation of the Hyaluronate Lyase Gene of <i>Streptococcus pyogenes</i>
<p><em>S. pyogenes</em> expresses many virulence factors, controlled by a complex regulatory network. These include hyaluronate lyase, an enzyme that degrades hyaluronic acid, a major component of the human extracellular matrix. Paradoxically, hyaluronic acid is also the sole component of the …
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Phagocytosis by neutrophils - studies on phagosome dynamics and membrane traffic modulation by Streptococcus pyogenes
… the engulfed microbe, but there are exceptions. Streptococcus pyogenes is one of our most common pathogens and is responsible for a wide range of diseases. Recently it has been demonstrated that these bacteria are able to survive phagocytosis by neutrophils. This doctoral thesis is about …
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Induction of myosin cross-reactive antibody and cytolytic T cell responses in mice with Streptococcus pyogenes
… common suppurative infections in man elicited by Streptococcus pyogenes that lead to autoimmune complications in susceptible individuals. Although the underlying mechanisms for the onset of post-streptococcal autoimmunity have yet to be established, experimental information gained thus far …
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Characterization Of Streptolysin O As The Translocator For The Cytolysin-Mediated Translocation Process In Streptococcus Pyogenes
… CMT) in <italic>Streptococcus pyogenes</italic> uses the pore-forming protein <underline>s</underline>trepto<underline>l</underline>ysin <underline>O</underline>: SLO) to translocate the <italic><underline>S.</underline></italic> …
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Identification of the role of the sal locus in streptococcus pyogenes virulence during host-pathogen interactions
<p>The pathogenesis of Streptococcus pyogenes is due to its ability to overcome and adapt to the harsh environment created by the host immune response. The focus of this project was the SalKR two-component regulatory system, which facilitates bacterial adaptation by responding to environmental …
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Studies of the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, with special reference to Streptococcus pyogenes infections and complement
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and Henoch-Schönlein purpura (HSP) the most common form of vasculitis in childhood. HSP may affect kidneys, a complication termed Henoch-Schönlein nephropathy (HSN). Renal pathology in HSN resembles that seen in IgAN. The …
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Cell Envelope Modifications By Lcp Family Proteins Of Group B Streptococcus And Virulence Singaling By Peptides Of The Salivaricin Locus Of Streptococcus Pyogenes
… MODIFICATIONS BY LCP FAMILY PROTEINS OF GROUP B STREPTOCOCCUS AND VIRULENCE SIGNALING BY PEPTIDES OF THE SALIVARICIN LOCUS OF STREPTOCOCCUS PYOGENES</p> <p>by</p> <p>HANNAH MORRISON ROWE</p> <p>December 2014</p> <p>Advisor: Dr. Melody Neely</p> <p>Major: Immunology and Microbiology</p> <p>Degree: …
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