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Showing 1 to 20 of 113 for “"Streptococcus pneumoniae"”.
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Investigating galactose metabolism in Streptococcus pneumoniae
Streptococcus pneumoniae is a formidable human pathogen. Responsible for between 1 and 2 million deaths annually, the pneumococcus makes a major contribution to global morbidity and mortality. In order to cause disease, the pneumococcus must first colonise the human nasopharynx. This colonisation …
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Genomic diversity in naturally transformable Streptococcus pneumoniae
Infections due to Streptococcus pneumoniae (the pneumococcus) remain a substantial source of morbidity and mortality in both developing and developed countries despite a century of research and the development of effective therapeutic interventions (such as antibiotic therapy and vaccination). The …
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Characterisation of Streptococcus pneumoniae opacity phase variation
Streptococcus pneumoniae (the pneumococcus) is a common nasopharyngeal commensal in humans that can invade deeper tissues causing a range of diseases, resulting in significant global morbidity and mortality. Any given strain of S. pneumoniae can undergo phase variation between two different colony …
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Biofilm formation and virulence of Streptococcus pneumoniae
S. pneumoniae is a genetically diverse species which complicates attempts to associate a given clonal lineage or serotype with propensity to cause disease; as well as in the identification of specific molecular determinants of distinct virulence phenotypes. Formation of biofilms is an important …
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Geographic Migration and Evolution of Streptococcus pneumoniae
Streptococcus pneumoniae (the pneumococcus) is a human-obligate, opportunistic bacteria. It resides asymptomatically in the nasopharynx of both children and adults. It occasionally goes on to cause local disease such as otitis media, or severe invasive disease as with pneumonia and meningitis. It …
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Molecular Characterization of Fluoroquinolone Resistance in Streptococcus pneumoniae
Streptococcus pneumoniae is a leading cause of respiratory tract infections, meningitis, and acute otitis media. The emergence of S. pneumoniae strains with resistance to the ß-lactam and macrolide antibiotics has complicated the treatment of pneumococcal infections and created a need for new …
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Infekuotų Streptococcus pneumoniae vaikų serologinių ir imunologinių parametrų tyrimai /
Streptococcus pneumonine is a gram-positive bacterial organism that colonizes the upper respiratory tract and causes diseases such as pneumonia, meningitis, otitis media, sinusitis and others. Disease rates are particularly high in young children. One of the aims of this study was to assess the …
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Molecular dissection of competence regulated virulence in Streptococcus pneumoniae
Streptococcus pneumoniae is an important human pathogen capable of entering the competent state naturally and acquiring DNA from the environment for recombination. In addition to improving genome plasticity, a natural competence system directly contributes to pneumococcal virulence during pneumonia …
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Mucins regulate virulence and colonization factors in Streptococcus pneumoniae
… opportunistic pathogens threatens human health. Streptococcus pneumoniae is a ubiquitous opportunistic pathogen, able to both asymptomatically colonize the microbiota of healthy children and adults and to cause invasive diseases. The mechanisms by which the body tolerates the presence of S. …
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Interferons in Influenza A Virus and Streptococcus Pneumoniae Co-Pathogenesis
… and IFN-γ pathways in the pathogenesis of IAV/ Streptococcus Pneumoniae (SPn) coinfection. Using gene knock-out models and neutralizing in vivo antibodies, we demonstrated that IFN-I and IFN-γ inhibit acute bacterial clearance post-IAV infection. However, IFN-γ plays a more critical role. …
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Ecology of virulence genes in the human pathogen Streptococcus pneumoniae.
Streptococcus pneumoniae, also known as the pneumococcus, is an important human pathogen, with high burdens of disease and mortality worldwide. There are over 90 serotypes of this pathogen, demonstrating the vast amounts of diversity present. Currently, there are two pneumococcal vaccines, both …
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Cirrhosis-Induced Defects in Innate Puemonary Defenses Against Streptococcus Pneumoniae
Streptococcus pneumoniae is the most common cause of community-acquired pneumonia, and this pathogen is especially detrimental for certain population groups, such as cirrhotic patients. It is well known that mortality from pneumococcal pneumonia is very high in those with cirrhosis, even when they …
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Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function
… to subsequent bacterial infection, often with Streptococcus pneumoniae (Spn). Clinical and experimental data indicate increased disease severity when a coinfecting agent is present during IAV infection, indicating the need to understand how the presence of a coinfecting pathogen can modulate …
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Viral and Bacterial Polymicrobial Interactions with Streptococcus pneumoniae in Otitis Media
… induce polymicrobial middle ear disease. <italic>Streptococcus pneumoniae</italic> is one of the two most commonly isolated bacterial pathogens of otitis media. This dissertation examines interactions of <italic>S. pneumoniae</italic> with nontypeable <italic>Haemophilus influenzae</italic>, the …
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The contribution of competence system to the virulence of Streptococcus pneumoniae
Competence induction in Streptococcus pneumoniae (pneumococcus) is initiated by the binding of the 17-amino acid competence stimulating peptide (CSP) to its membrane-associated histidine sensor kinase ComD. ComD autophosphorylates and subsequently phosphorylates and activates its cognate response …
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An investigation towards a conjugate vaccine against Streptococcus pneumoniae serotype 19A
Streptococcus pneumoniae is a human pathogen that causes invasive pneumococcal diseases (IPD) such as pneumonia, otitis media and sepsis particularly in children, the elderly, and patients with HIV, and other immunosuppressive conditions. Conjugate vaccines comprised of the bacterial surface …
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Molecular modelling of the Streptococcus pneumoniae serogroup 6 capsular polysaccharide antigens
… of the capsular polysaccharides of Streptococcus pneumoniae is conducted using Molecular Modelling methods. S.pneumoniae causes invasive pneumococcal disease (IPD), a leading cause of death in children under five. The serotypes in group 6 are amongst the most common of IPD causing …
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STUDIES ON THE OPSONIZATION OF STREPTOCOCCUS PNEUMONIAE BY HUMAN C-REACTIVE PROTEIN.
STUDIES ON THE OPSONIZATION OF STREPTOCOCCUS PNEUMONIAE BY HUMAN C-REACTIVE PROTEIN.
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