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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Stra8"”.
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Zur Rolle von Stra8 in pluripotenten Stammzellen
In der vorliegenden Arbeit sollte das Gen Stra8 (Stimulated by retinoic acid gene 8) hinsichtlich seines Expressionsmusters und seiner Rolle in pluripotenten Zellen genauer untersucht werden. Stra8 ist ein Keimzell-spezifisches Gen, das in der prämeiotischen Phase der Spermatogenese exprimiert …
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A molecular characterization of the meiotic initiation factor STRA8 in mice
… gene Stimulated by retinoic acid 8 (Stra8) is required to initiate all events of meiotic prophase I. The STRA8 protein has long been assumed to be a transcription factor, but in vivo biochemical evidence of its function has been lacking. I present evidence demonstrating that STRA8 …
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The Role of Stra8 in spermatogenesis : regulation of spermatogonial differentiation, meiotic initiation, and testicular tumor formation
… I will present my findings demonstrating that Stra8, previously demonstrated to be a RA-induced gene, is a target gene of RA in both the transition from undifferentiated spermatogonia to differentiating spermatogonia and the transition from mitosis to meiosis. I conclude that RA inducing Stra8 …
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Expression and functional analysis of <i>Tex18</i> and <i>Stra8</i> genes in male germ cells
… der beiden Testis- spezifischen Gene Tex18 und Stra8. Die RT- PCR- Expressionsanalyse des Gens Tex18 zeigte eine Expression ausschließlich in männlichen Keimzellen. Außerdem konnte die Expression von Tex18 in Entwicklungsmutanten (mit Ausnahme von W/WV- Mäusen, welche keine Keimzellen besitzen) …
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The genomic and genetic basis of mammalian sexual reproduction : sequence of the mouse Y chromosome, and a gene regulatory program for meiotic prophase
… over time and space, and in mutants of Dazl and Stra8 - key genes required for meiotic initiation. We determined that genes are regulated in three classes. Class 1 genes are expressed independently of Stra8, class 2 genes are expressed partially independently of Stra8, and Class 3 genes are …
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The role of retinoic acid in germ cell development in embryonic mouse gonads
… embryonic ovaries, because it is necessary for Stra8 (Stimulated by retinoic acid gene 8) expression. Stra8 is required for pre-meiotic DNA replication in embryonic ovaries and it is only expressed in testes after birth. I also show that a cytochrome p450 enzyme CYP26B 1, specifically expressed …
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Deciphering the mitotic and meiotic phases of spermatogenesis in the mouse
… of spermatogenesis. Chapter 2 describes how RA-STRA8 signaling regulates two key transitions: spermatogonial differentiation, which begins the transit-amplifying mitotic divisions, and meiotic initiation, which ends them. First, in mice lacking the RA (retinoic acid) target gene Stra8, …
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Zur Pluripotenz Spermatogonialer Stammzelllinien
… Rolle des Spermatogonien- spezifischen Markers Stra8 untersucht. Als weiterer Aspekt wurde die in vitro Spermatogenese von SSC- Zelllinien untersucht. Als letzten Gesichtspunkt wurde im Rahmen der vorliegenden Arbeit die Isolierung und Kultivierung humaner spermatogonialer Stammzellen untersucht.
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A role for the Speedy gene family in the early stages of mammalian meiosis
… ovary and its expression to be dependent on Stra8.
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MicroRNA Expression Profiling of Multipotent Adult Germline Stem Cells
… sich undifferenzierte maGSCs aus der transgenen Stra8-EGFP-Rosa-Maus von allen anderen untersuchten Zelltypen. miRNAs, der 290 und 302 Familie, sind als ESC spezifisch bekannt. In dieser Arbeit konnte gezeigt werden, dass diese miRNAs neben undifferenzierten ESCs auch in anderen pluripotenten …
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A role for Dazl in commitment to gametogenic fate in embryonic germ cells of C57BL/6 mice
… resemble embryonic XX germ cells deficient for Stra8, a gene required for meiotic initiation.
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Analysis of the Role of Piwil2 gene in Tumorigenesis and Germline Stem Cell Metabolisms
… Marker Hsp90α (Heat shock protein 90 alpha) und Stra8 (Stimulated by retinoic acid gene 8). Diese Moleküle spielen eine essentielle Rolle bei der Stammzellproliferation (Pdgfrb), dem Zellmetabolismus (Slc2a1), der Zelladhäsion, der Zell-Zell-Interaktion (Itga6, Gja7, Thy-1 und CD9) und der …
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Gene expression changes during mammalian male meiotic initiation
… Type A spermatogonia, Type B spermatogonia, STRA8- preleptotene spermatocytes, loSTRA8 preleptotene spermatocytes, hiSTRA8 preleptotene spermatocytes, and leptotene spermatocytes. Following transcriptome sequencing, data analysis showed several different patterns of gene expression during …