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Showing 1 to 7 of 7 for “"Stetter reaction"”.
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Development of a catalytic enantioselective intramolecular Stetter reaction: catalyst development and synthetic applications
… enantioselective intramolecular Stetter reaction has been developed. The process involves direct conversion of an aldehyde into a chiral acyl anion equivalent and its addition into a pendant electron-deficient olefin. The development of chiral bicyclic nucleophilic carbene …
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The Stetter reaction : synthesis of complex spiro Bis-indanes and studies on quaternary centre formation
This work covers recent advances in the Stetter reaction, including two novel domino Stetter reactions and preliminary studies on quaternary center formation via the intermolecular Stetter reaction. The N-heterocyclic carbene (NHC) catalyzed domino Stetter-aldol-Michael dimerization of o-formyl …
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Carbene catalyzed asymmetric nucleophilic acylations with novel triazolium salts
… the benzoin condensation and intramolecular Stetter reaction. The optimal conditions were identified and allowed for an expansion of the reaction scope with 8-95% yield and enantiomeric excesses of 21-95% in the benzoin condensation. Furthermore, these carbene precatalysts have been applied …
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Neue Heterazoliumsalze aus Prolin und Pyroglutaminsäure und Anwendungen in Carben-katalysierten asymmetrischen nucleophilen Acylierungen
… that the catalytically active species of these reactions is a nucleophilic carbene. Consequently, enzyme mimetic asymmetric catalytic processes that are mediated by nucleophilic carbenes in vitro as, for instance, the benzoin condensation, the Stetter and other related nucleophilic acylation …
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Preparation of Novel Carbenes and their Catalytic Application to the Cross-Benzoin, Aza-Benzoin and Stetter Reactions
… different unbranched aliphatic aldehydes. The reaction was also effective with ortho, meta or para substituted aromatic aldehydes (possessing either electron donating or withdrawing substituents) and was tolerant to α and β branched aliphatic aldehydes as well. A library of …
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Entwicklung von Carben-katalysierten asymmetrischen intermolekularen Stetter-Reaktionen und direkt gekreuzter intermolekularer Benzoin-Reaktionen
… employed in the asymmetric intermolecular Stetter reaction. The resulting 1,4-diketones were obtained in moderate to excellent yields (49-98%) and good enantioselectivities (56-78% ee). For several Stetter products the enantiomeric excess could be enhanced by a single recrystallization up …
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Design and Synthesis of Chiral Triazolium and Thiazolium Salts Incorporating Hydrogen-Bonding Motifs as Organocatalysts
… Originally catalysed by the cyanide anion, the reaction can also proceed with thiamine as a catalyst. Since then, many N- heterocyclic carbene (NHC) catalysts have been developed for use in umpolung reactions between aldehydes and a range of coupling partners. However, stereoselectivity of the …