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Showing 1 to 10 of 10 for “"Sterol Regulatory Element Binding Proteins"”.
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
<p>Precise regulation of cholesterol levels is necessary for survival of individual cells and the normal functioning of multicellular organisms. Many of the genes important in these processes are regulated at a transcriptional level by the sterol regulatory element binding proteins (SREBPs) and …
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SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
Cholesterol synthesis in mammalian cells is highly regulated by an end-product feedback mechanism. The transcription of genes necessary for both fatty acid and cholesterol production are controlled by sterol regulatory element binding proteins (SREBPs). The critical regulatory step is the …
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The Influence of Adenoviral Infection and the Group VIA Calcium-Independent Phospholipase A2 on Hepatic Lipid Metabolism
Sterol regulatory element-binding proteins (SREBP) are transcription factors that regulate genes involved in lipid metabolism especially in the liver. Therefore, hepatic SREBP is significant regulator of systemic lipid metabolism. Evidence demonstrates that insulin and dietary unsaturated fatty …
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An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
<p>Regulation of cholesterol levels within cells and organisms is crucial for their survival. Maintenance of cellular cholesterol homeostasis occurs mainly at the transcriptional level, via the Sterol Regulatory Element Binding Proteins (SREBP), the Liver X Receptors (LXR), and the Unfolded Protein …
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Alternative Processing of SREBP in Site 2 Protease and Scap Mutants During Larval Development in Drosophila Melanogaster
… by the membrane-bound transcription factor, sterol regulatory element binding protein (SREBP). SREBP requires release of the amino terminus from the membrane to activate transcription of genes involved in cholesterol and fatty acid synthesis. In response to low sterol levels, Scap escorts …
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Alternative Processing of SREBP in Site 2 Protease and Scap Mutants During Larval Development in Drosophila Melanogaster
… by the membrane-bound transcription factor, sterol regulatory element binding protein (SREBP). SREBP requires release of the amino terminus from the membrane to activate transcription of genes involved in cholesterol and fatty acid synthesis. In response to low sterol levels, Scap escorts …
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Fatty Acid Auxotrophy in Drosophila Larvae Lacking SREBP
… transcription factor, dSREBP (Drosophila Sterol Regulatory Element Binding Protein), is essential for the maintenance of this prototrophy. Drosophila larvae lacking dSREBP demonstrate a profound growth deficit in the second instar and die before reaching third instar. This is accompanied …
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Characterization of Drosophila Scap: Analysis of Mutants and Evidence for a Retention Factor
The SREBP pathway is one of the major regulators of lipid homeostasis and it is highly conserved among metazoans. SREBP is a transcription factor whose precursor is an endoplasmic reticulum (ER) transmembrane protein. In order to be activated it must travel to the Golgi apparatus via interaction …
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… that LPA induced proteolytic activation of sterol regulatory element binding proteins (SREBPs) in a cancer specific manner, leading to activation of the SREBP-FAS (fatty acid synthase) lipogenic pathway. Treatment of cancer cell lines with LPA also led to dephosphorylation and inhibition of …
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Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
Low density lipoproteins (LDL) and related plasma lipoproteins deliver cholesterol to cells by receptor-mediated endocytosis. The lipoprotein is degraded in late endosomes and lysosomes, allowing cholesterol to be released. Export of cholesterol from late endosomes and lysosomes (hereafter referred …