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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 171 for “"Sterol"”.
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A Comparative Study of the Sterol Biosynthetic Pathway in Sterol-Synthesizing and Non-Sterol-Synthesizing Fungi
Made available in DSpace on 2014-12-14T04:37:39Z (GMT). No. of bitstreams: 1 7616214.pdf: 6721025 bytes, checksum: f44198700cbaf5ce82ec9d5790f8ac08 (MD5) Previous issue date: 1976
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Sterol requirements in Drosophila melanogaster
Sterol is an abundant component of eukaryotic cell membranes and is thought to influence membrane properties such as permeability, fluidity and microdomain formation. Drosophila is an excellent model system in which to study functional requirements for membrane sterol because, although it does not …
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Genetic Determinants of Human Serum Sterol Levels
Dozens of different cholesterol metabolites are synthesized by mammalian cells and are known to play important physiological roles in the liver, brain, and immune system. These metabolites are ultimately inactivated by conversion into bile acids in the liver and are thereafter excreted from the …
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The Role of ABCG5/G8 in Sterol Homeostasis
THE ROLE OF ABCG5/G8 IN STEROL HOMEOSTASIS
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Membranous sterol dynamics and interactions with amphotericin B
Sterols are ubiquitous membrane-active molecules that regulate the fluidity cellular membranes. Specifically, cholesterol (Chol) plays an active role in modifying the functionality of the membrane proteins. Chol is vital for cell function, as it is essential to a myriad of biochemical and …
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The Influence of Age and Sterol-Inhibiting Fungicides on the Sterol and Steryl Ester Composition of SIF Sensitive and Tolerant Non-Target Chlorella Species
… form a class of agricultural chemicals known as sterol-inhibiting fungicides (SIFs). These fungicides function through the inhibition of sterol synthesis, which ultimately affects cell membrane fluidity and permeability. Of the two main types of sterols in plants, free sterols (FSs) are thought …
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Interactions of the sterol and lipid biosynthetic pathways in yeast
Um neue Interaktionen zwischen dem Sterol- und anderen Lipidbiosynthesewegen zu identifizieren, wurde Saccharomyces cerevisiae genetisch verändert und der Gehalt der Fettsäuren und der Sterole wurde indiesen Stämmen untersucht. Die Überexpression von ACC1 im Wildtypstamm und im HMG-deregulierten …
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Characterization of ARV1-Mediated Sterol Transport in Yeast and Mammalian Systems
… was initially observed to mediate subcellular sterol distribution, and has since been implicated in the movement of multiple lipid species. In this thesis, we examined the role of ARV1 in S. cerevisiae and mammalian systems by two approaches. In yeast, we used gene deletion to access loss of …
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The Effects of Luteinizing Hormone on Sterol Metabolism in The Ovary
Made available in DSpace on 2015-05-13T22:12:03Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7021021.PDF: 6099438 bytes, checksum: b0d6ce4171d75c587a5966ecade01d78 (MD5) Previous issue date: 1970
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An investigation of genetic factors impacting sterol profiles in Australian olive oils
Analyses of phytosterol levels in Australian olive oils derived from the cultivar Barnea (Olea europaea L. cv. Barnea)reveal up to 4.8% campesterol, exceeding the IOOC standards that stipulate a level of <4%. It has been observed that sterol profiles appear to remain relatively consistent within …
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Autogramin-2, a synthetic sterol, inhibits T cell adhesion and effector function
Plasma membrane resident cholesterol is a key regulator of T cell immunity as it stabilises immune synapses, thus supporting effector T cell function. Recent publications suggest that increasing plasma membrane cholesterol content boosts anti-viral and anti-cancer immunity in T cells. Inhibition of …
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Structural Studies of Integral Membrane Proteins Involved in GPCR Signaling and Sterol Homeostasis
… both sense and respond to differences in cholesterol levels within the ER membrane. Scap is a central player in the SREBP pathway, which is targeted by multiple classes of pharmaceuticals, including statins. Through efforts described in the second half of this dissertation, I have been able to …
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Elucidation of the mycosamine dependent sterol binding and antifungal activities of amphotericin B
… that is dependent on the presence of membrane sterols to exert its biological activity. This natural product has been shown to form ion channels in model membrane systems and therefore represents a molecule with the capacity to perform protein-like function, i.e. the formation of a …
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Regulation of sterol regulatory element binding protein-1 in bovine mammary epithelial cells
The key transcription factor sterol regulatory element binding protein-1 (SREBP1) plays a central role in milk fat synthesis. SREBP1 stimulates the transcription of genes encoding lipogenic enzymes. The overall objective of these studies was to investigate the mechanisms of SREBP1 regulation by …
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Synthese des antimykotisch aktiven Steroid-Alkaloids Plakinamin B - Azasteroide als Inhibitoren der Sterol-C-24-Methyltransferase
… Aktivität in einem Agar-Diffusionstest; Ergosterol-Biosynthese-Inhibitor-Screening und Bestimmung des jeweiligen Zielenzyms; Ableitung von Struktur-Wirkungs-Beziehungen.
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Physiological and ultrastructural effects of sterol-inhibiting fungicides on apple leaves and the apple scab fungus
The effects of sterol-inhibiting fungicides (SIFs) on the free sterol and free fatty acid composition of apple leaves of Red Delicious and Jonathan cultivars were examiried over a 2 year period. Trees were treated in mornings vs evenings throughout each season and samples collected after 24 and 72 …
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Sterol Binding to Niemann-Pick Type C1 Disease Protein (NPC1) - Implications for its Function in Cholesterol Transport
… many pathways involved in the transport of cholesterol within cells. Despite intense scientific interest, the mechanism by which cholesterol is transported between membrane compartments in animal cells remains obscure. Studies on Niemann-Pick type C disease (NPC) defined the requirement of at …
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