Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Steroidogenic factor-1"”.
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The role of steroidogenic factor-1 (SF-1) in gonadotropin-releasing hormone (GnRH) receptor gene regulation
… have been shown to regulate GnRHR expression. Steroidogenic Factor-1 (SF-1), a member of the orphan nuclear receptor transcription factor family, regulates the expression of both the gonadotropin hormones in the pituitary and the steroidogenic enzymes in the gonads and adrenal gland, and …
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A four-and-a-half LIM protein FHL2 acts as a coactivator for the Wilms' tumor suppressor WT1 during gonadal differentiation
… suppressor (WT1) and the orphan nuclear receptor steroidogenic factor 1 (SF-1) bind cooperatively to the promoter of MIS and activate its transcription. In the ovary, on the other hand, the orphan nuclear receptor DAX-1 binds to SF-1. The binding inhibits WT1/SF-1 transactivation and thereby …
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Epigenetic Regulation of Nuclear Hormone Receptor DAX-1
… a key role in the development and maintenance of steroidogenic tissue in mammals. Dax-1 is also expressed in mouse embryonic stem (ES) cells and is required to maintain pluripotency. Duplication of the X-chromosome in the region containing the NR0B1 gene results in sex reversal, and mutations in …
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Identifying the mechanism critical for proliferation, apoptosis, and cell-cell interaction in the development of mouse adrenals and gonads
Adrenal, testis, and ovary are steroidogenic organs derived from a common primordium that consists of Steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs, but also controls their differentiation. In this thesis project, I used …
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SF-1, BUT NOT DAX-1, PREVENTS P19 CELLS FROM DIFFERENTIATING TO EITHER TROMA-1 OR TUJ1 POSITIVE CELLS UPON RA-TREATMENT
… increase in Pre-â cell leukemia transcription factors (PBX) mRNA and protein levels in P19 cells prevents them from differentiating to either endodermal or neuronal cells. This suggests that PBX is an important regulator of RA-induced differentiation of P19 cells. A microarray analysis was …
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Regulation of Adrenal Steroidogenesis by Interleukin-6
… enzymes involved in cortisol and DHEA synthesis, steroidogenic factor-1 (SF-1), steroidogenic acute regulatory protein (StAR), and dosage sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX-1). In human H295R cells and bovine zona fasciculata cells …
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Regulation und Expression von P450scc im Nervensystem
… im Wesentlichen durch die Transkriptionsfaktoren Steroidogenic Factor -1 (SF-1) und Sp1 reguliert, die an konservierte DNA-Elemente im Promoterbereich des CYP11a1-Gens binden können. Im Nervensystem wird P450scc vornehmlich in Zellen glialen Ursprungs exprimiert. Im Gegensatz hierzu wird SF-1 nur …
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A Molecular Dissection of the Ventromedial Hypothalamic Nucleus
… expression profile. One of the VMH markers, steroidogenic factor 1 (SF-1), is an orphan nuclear receptor with few known target genes. As this transcription factor is responsible for proper developmental formation of the VMH and also for normal energy homeostasis, we endeavored to determine …
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The role of beta-catenin in the development of fetal ovary and female germ cells
… with β-catenin being ablated specifically in the steroidogenic factor 1 (SF1)-positive population of somatic cells of the fetal gonads. In the absence of β-catenin, fetal testis developed normally whereas unique phenotypes appeared during the development of ovary. These phenotypes included …