Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Steroid receptors"”.
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DNA Bending by Steroid Receptors
… occupied ER. Constitutively active mutant receptors had directed DNA bending angles similar to estrogen occupied WT ER. These findings imply that transcriptionally active mutant ERs induce directed bending angles that are similar to the DNA bend induced by WT ER.
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Small molecule inhibitors of steroid receptors for breast and prostate cancer
Steroid hormone receptors play a critical role in the growth and progression of hormone-dependent cancers. This thesis aimed at identifying and characterizing new chemical entities with therapeutic potential in breast and prostate cancer treatment. Reported here are two inhibitors that antagonize …
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Modulators of Inflammation and Steroid Receptors Regulate Proteinase Inhibitor 9 Gene Expression
In addition to pro-inflammatory agents, the synthetic anti-inflammatory glucocorticoid, dexamethasone, induced PI-9 gene expression via an imperfect glucocorticoid response element (GRE) located at -208. Dexamethasone induced PI-9 mRNA and protein. Dexamethasone-glucocorticoid receptor (GR) complex …
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Central Expression of Sex Steroid Receptors during the Ring Dove (Streptopeliarisoria) Breeding Cycle
… in birds brooding young. The association between steroid receptor expression and aromatase P450 enzyme(P450AROM)activity in the brain of the ring dove was also investigated. Sexually experienced ring doves were injected intramuscularly with the aromatase inhibitor fadrozole (0.2 ml of 1 mg n-A-') …
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Localisation of sex steroid receptors and effect of Tamoxifen upon glioma cell lines in vitro
… As well as its effect in blocking estrogen receptors, Tamoxifen is also known to exert antiproliferative effects via non-receptor mediated mechanisms including the blockage of Protein Kinase C, inhibition of the Mitogen-7 Activated Protein Kinase (MAPK) family among a vast array of cellular …
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Effects of Stress, Circadian Rhythms, and Dietary Sodium on Brain Cell-Nuclear Uptake of Aldosterone and Corticosterone (Steroid Receptors)
The binding of the adrenal steroid hormones aldosterone (ALD) and corticosterone (CORT) in brain cell-nuclei has been implicated as a necessary step in the behavioral and physiological actions of these hormones. In vivo uptake of radioactively labeled ALD and CORT in adrenalectomized (ADX) rats …
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The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer
<p>The use of hormone replacement therapy (HRT) is important to relieve menopausal symptoms. However, HRT use declined after an increased risk of breast cancer was reported by the Women's Health Initiative. With the ultimate goal of developing a novel replacement therapy to relieve menopausal …
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Development and Application of a Fluorescence Anisotropy Microplate Assay for Analyzing the Interaction of Steroid Hormone Receptors With DNA and Coactivators
… to the binding of estrogen and progesterone receptors to their respective DNA response elements. The FAMA is also the first system suitable for screening large compound libraries to identify novel compounds that modulate binding of steroid receptors to their DNA response elements. …
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I.~fluorine-18 Labeled Corticosteroids and Progestins for Receptor-Based Imaging of the Brain and of Breast Tumors. II.~Synthesis and NMR Spectrum of (carbon-13(18))-Meso-Hexestrol
The presence of steroid receptors in certain target tissues and tumors provides an avenue for monitoring pathological changes through the use of positron emission tomography and an appropriate fluorine-18 labeled ligand. We have prepared fluorinated analogs of six natural and synthetic …
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Differential effects of progestogens on HIV-1 replication and host gene expression in primary PBMCs and cervical tissue explants
… differential selectivity to towards different steroid receptors, in particular the glucocorticoid receptor (GR). In order to investigate this hypothesis, the regulation of selected genes was investigated in cervical tissue explants from premenopausal, HIV-1negative, and contraception negative …
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Determining the endometrial phenotype of women with abnormal uterine bleeding
… conditions. Fibroids and adenomyosis are sex-steroid dependant conditions, and lines of evidence suggest there is an impaired progesterone response in the endometrium from women with adenomyosis, however, there is a dearth of evidence related to the endometrium from women with fibroids. Women …
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Biosynthesis and Signaling of Glucocorticoids and Progestins and Their Effects on Myelin Synthesis in Schwann Cell/neuronal Co-Cultures
… nerve impulses in a fast and efficient manner. Steroids hormones can be synthesized de novo in the nervous system. The major objective of this research was to identify the steroid signal transduction pathways between neurons and Schwann cells that regulate the steps in myelin formation. Schwann …
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The role of p90 ribosomal S6 kinases (RSKs) in Steroid signalling
… by RSKs, several studies have identified the Steroid Receptors (SRs) as substrates of the RSKs. SRs are a subfamily of the nuclear receptor superfamily consisting of five proteins (androgen, glucocorticoid, estrogen, progesterone and mineralocorticoid receptors). These proteins regulate gene …
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Characterisation of Androgen Receptor Variants in Breast Cancer and the Development of Thieno[2,3-b] Pyridines as Novel Anti-Cancer Compounds
In Breast Cancer(BCa), steroid receptors play a key role in the progression of the majority tumours. Oestrogen Receptor-α (ERα), for example,drives the growth of approximately 70% of tumours and is therefore a useful therapeutic target for this disease.Interestingly, the Androgen Receptor (AR) is …
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I. Molecular Probes for the Progesterone Receptor. II. Design and Synthesis of a Rigidly Constrained Peptidomimetic as a Potential Beta-Turn Mimic. III. Isolation and Characterization of Novel Ion Channel Modulators From Commercial Phenol Red Preparations
Chemical probes for steroid receptors have proven useful in providing molecular details about important hormone-receptor interactions. $16\alpha,17\alpha$- ((R)-1$\sp\prime$-(4-Azidophenyl)-ethylidenedioxy) pregn-4-ene-3,20-dione (12) was prepared in high specific activity tritium-labeled form (20 …
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Small molecule inhibitors: novel probes of progesterone receptor action
… limited cross-reactivity for inhibiting other steroid receptors, estrogen receptor (ER), glucocorticoid receptor (GR), and androgen receptor (AR). Our in vitro studies show that these inhibitors do not act by blocking PR binding to the progesterone response element on DNA. One class of …
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Modulation of Cerebral Artery Smooth Muscle BK Channel Function by Neurosteroids
… with few off-target effects. While many steroids have been implicated to have vasoactive effects, including but not limited to, pregnenolone and progesterone, these effects have been mainly attributed to the actions produced by the activation of traditional steroid receptors. Importantly, …
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Metabolic and mechanistic exploration of a novel programmable genotoxicant against prostate cancer
… are designed to utilize proteins such as steroid receptors that are abnormally expressed in cancers to enhance toxicity and specificity. The synthetic phase of this project successfully produced a compound, 11P, that when tested against cancer cell lines demonstrated remarkable potency, …
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EGFR Signaling Is Necessary for Gonadotropin-Induced Steroidogenesis and Oocyte Maturation
… critical for normal female fertility, including steroidogenesis, oocyte maturation, and subsequent ovulation. Studies were designed to examine the LH-induced signaling pathways that regulate ovarian steroidogenesis, as well as the subsequent role of steroids and their receptors on oocyte and …
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Estrogen in ovarian cancer cell metastasis
… majority of epithelial ovarian cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and metastasis. Tumor cells …
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