Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Steroid Hydroxylases"”.
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Role of Cholesterol 24-Hydroxylase in Hippocampal Long-Term Potentiation
The mammalian brain contains a disproportionately large percentage of the body's cholesterol, steady-state levels of which are maintained within a narrow range to preserve membrane function. The brain is denied access to circulating lipoproteins by the blood-brain barrier and therefore relies on de …
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Genetic Determinants of Human Serum Sterol Levels
Dozens of different cholesterol metabolites are synthesized by mammalian cells and are known to play important physiological roles in the liver, brain, and immune system. These metabolites are ultimately inactivated by conversion into bile acids in the liver and are thereafter excreted from the …
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Identification of an Interferon Signaling Pathway Linking Membrane Cholesterol Accessibility to Host Defense Against Pathogens
Interferon-γ (IFN-γ) is a multipotent cytokine that is critical to the host innate immune defense against bacterial infection, and functions through transcriptional induction of hundreds of IFN-γ stimulated genes (γ-ISGs). However, the antibacterial roles of many γ-ISGs remain poorly defined. Here, …