Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Sterile Filtration"”.
-
A multifaceted approach towards advancing the sterile filtration of therapeutic viruses
… and purification of these products, the sterile filtration unit operation is known to have poor yields and contribute to the high cost of the final product, significantly hampering the large-scale production of some therapeutic viruses. Thus, this thesis seeks to explore various aspects …
-
A preliminary investigation of the sterile-filterability of BCS class II drug nanosuspensions prepared via wet stirred media milling
… bioavailability when injected intravenously. Sterile filtration of drug nanoparticle suspensions (nanosuspensions) is critically needed for administration by intravenous delivery route. Avoiding gamma irradiation and high temperatures, sterile filtration could be an effective process to …
-
Screening and Engineering Phenotypes using Big Data Systems Biology
… analysis with RametrixTM. Specifically, sterile filtration was tested as a potential method for extending the duration at which samples may be kept at room temperature prior to Raman analysis. Sterile filtration was shown to alter the chemical profile initially, but did not prevent …
-
Addressing the Downstream Processing Challenges Within Manufacturing of Oncolytic Rhabdoviruses
… of membranes in downstream processing is for the sterile filtration of OVs, which is a required final step that is conducted right before vialing and involves passing the virus particles through a validated sterile filter. One of the main objectives of this thesis was to develop a fundamental …
-
The use of non-ionic surfactant vesicles to prevent radiocontrast media-associated damage
… processing through ultracentrifugation or sterile filtration did not significantly alter physical properties. IOX-NIVs maintained physicochemical stability throughout 37 weeks storage at 4 and 25 °C. A time- and temperature-dependent change in IOX-NIV colour was observed prior to an …