Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Stereocontrolled Synthesis"”.
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Stereocontrolled synthesis of plant growth regulators Abscisic acid and Xanthoxin
The project is concerned with the total synthesis of plant growth regulators related to abscisic acid (ABA). The biological activity of these plant growth regulators, ABA and Xanthoxin, and their derivatives is influenced by the stereochemistry of the double bond system in the side chain, the …
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TEMPLATE DIRECTED C-H INSERTION REACTIONS FOR STEREOCONTROLLED SYNTHESIS OF HETEROCYCLES
Template Directed C-H Insertion Reactions for Stereocontrolled Synthesis of Heterocycles Orobosa Marvis Erhunmwunse, PhD. Non aromatic heterocycles and their analogues are abundant in a large variety of bioactive natural products and continue to play crucial roles in modern day chemotherapy. The …
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Modular Synthesis and Hydroalkylation of Vicinally Functionalized Ketopiperazines: A solution to the Piperazine Problem
The stereocontrolled synthesis of functionalized piperazines is of great interest to pharmaceutical companies owing to their multiple biological activities such as antidepressant, antiparasitic, anticancer and antiretroviral. Current methods towards functionalized piperazines include intramolecular …
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Cycloaddition-fragmentation mediated pathways to ring D modified 19-norsteroids
An efficient strategy for the synthesis of 14β-3'-oxobutyl 19-norsteroids has been developed and the intramolecular reactivity of the derived compounds has been investigated. The approach is based on cycloaddition of methyl vinyl ketone to 3-methoxyestra-1,3,5(10),14,16-pentaen-17-yl acetate which …
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Studies towards the total synthesis of madeirolide A
… natural product makes it a compelling target for synthesis. This thesis discloses synthetic efforts towards the total synthesis of madeirolide A with an emphasis on the construction of the all-cis C21 – C27 eastern tetrahydropyran. [Figure] Chapters 1 and 2 provide an introduction to the …
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Stereoselective synthesis of perhydrobenzo[4.5.6]cholestanes
… reaction sequence has been developed for the stereocontrolled synthesis of pentacyclic steroids! with the new six-membered ring attached to the C(4) and C(6) positions. Cholesterol was converted into 3β-hydroxycholest-4-en-6-one by standard methods, and the corresponding 3α-isomer was obtained …
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Total synthesis and study of the antilipoperoxidant peridinin, synthesis of versatile MIDA boronate building blocks, and a general strategy for the synthesis of polyenes
… we completed an efficient, flexible, and fully stereocontrolled synthesis of the carotenoid natural product peridinin. This natural product inspired the development of new methodology, including the stereocontrolled Suzuki-Miyaura cross-coupling of haloallenes and the transesterification of …
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The Synthesis-Enabled Stereochemical Elucidation of the Marine Natural Products Hemicalide and Phormidolide A
… and/or absolute configuration is unknown, total synthesis becomes a powerful method to enable their structural elucidation, as highlighted in Part I. This thesis discusses synthetic efforts towards two marine natural products, hemicalide (1) and phormidolide A (2), with the end goal of …