Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"Stem-Like Cells"”.
-
Metakaryotic biology : novel genomic organization in human stem-like cells of fetal-juvenile development and carcinogenesis
… and tumors, including bell-shaped nuclei with stem-like properties. These bell-shaped, or "metakaryotic," nuclei are abundant in fetal tissues and neoplasias, but rare in normal adult somatic tissues. Metakaryotic nuclei employ an unusual process for division in which DNA synthesis, partial …
-
ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… NADPH. We observed that normal breast epithelial cells MCF10A cells have very low level of FAS expression whereas breast cancer cell lines MCF7, MDA MB231 and MDA MB231 LM have significant overexpression. Next, we observed the similar trend of FAS overexpression in breast cancer stem-like cells …
-
Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
… of GBM have suggested the presence of stem-like cells that have the ability to initiate and maintain tumors of a heterogeneous nature, and bestow resistance to current therapeutic regimens. It is therefore imperative to identify the dysregulated molecular pathways which enable the …
-
Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… model (TIC) states that tumors are composed of cells that form the majority of the tumor and are terminally differentiated. This model however, attributes tumorigenesis, metastasis and chemoresistance to a distinct cell population with a stem-like phenotype that can be identified using selective …
-
Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance
… subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. In addition, we have studied the functional retinoblastoma tumour suppressor (RB) protein pathway and associations to tamoxifen response. Furthermore, the expression of …
-
ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor progression. We have analyzed the expression profiles of various Notch liagnds in 779 breast cancer patients in GEO database and found that the expression of Jagged2 among all five …
-
ROLE OF SPARC IN DORMANCY OF PROSTATE CANCER IN THE BONE
… recur in the bone; however, how dormant cells switch its phenotype leading to recurrent tumor remains poorly understood. We have isolated two syngeneic cell lines (Indolent and Aggressive) through in vivo selection by implanting PC3mm stem-like cells into the tibial bones. We found that …
-
Liver fluke development: a target for parasite control?
… have identified a population of proliferative cells within Fasciola hepatica (Fasciola proliferative cellsFPCs) that resemble neoblast-stem cells, both morphologically and behaviourally. These cells are the only proliferating cells in Fasciola hepatica and can be localised using thymidine …
-
Investigating The Role Of Chaperone-Mediated Autophagy In Glioma Stem Cells
… median survival of less than 2 years. Cancer stem/propagating cells (CSCs) are functionally defined by the enriched capacity to propagate tumors in vivo, as well as self-renewal and differentiation potentials to establish cellular hierarchy and heterogeneity. Numerous studies support that GBMs …
-
Physicochemical characterization of immortal strand DNA
… the generation of distinct cell types from adult stem cells (ASCs). Current understanding of tissue differentiation mechanisms is based on studies of protein and RNAs that asymmetrically segregate between daughter cells during embryogenesis. Whether or not other types of biomolecules segregate …
-
LOCO-REGIONALLY TARGETING INTERLEUKIN-13 RECEPTOR ALPHA-2 AND MAXIMIZING THERAPEUTIC ACCESS TO GLIOBLASTOMAS USING BIOMARKER DIRECTED ALPHA PARTICLES
… overexpressed by therapy resistant, diving GBM stem-like cells (GSCs) (Nguyen et al, Translational Oncology 2011). Targeting such a GBM restricted biomarker, especially one that is also expressed by GSCs to deliver cytotoxic therapeutics and diagnostic agents could potentially lead to early …
-
Monte Carlo simulations, in vitro and in vivo experimental verifications for preclinical studies
… the role of hypoxia in primary GBM cancer stem-like cells was investigated using two radiation qualities (X-ray and alpha particle beams). - Biological effectiveness along SOBP by means of in vivo experiments using skin deterministic damage as endpoint in mice. Nevertheless, further studies …
-
Differential Pax5 Levels Promote Mcl Dispersal and Progression and Predict A Poor Prognosis In Advanced Mcl Patients
… significantly repressed compared to normal B cells. Surprisingly, we found there were quantitative differences in PAX5 expression levels within MCL patient tissues, which prompted us to silence PAX5 in MCL cell lines to characterize PAX5 functions in MCL disease progression. PAX5 silencing in …
-
The emerging roles of BAP1 and cancer stem cells in Malignant Mesothelioma
… demonstrated that BAP1 mutated and silenced MMe cells are more resistant to a DNA damage drug, gemcitabine, causing the reduction of the DNA damage effect of gemcitabine. These finding suggested that BAP1 modulates chemosensitivity though DNA damage response and provided a potential route for …
-
Identification of a novel autonomous role for Ecdysone Receptor during Drosophila ovarian germ cell differentiation
… coordinates the division of Drosophila germline stem cells (GSCs) and differentiation of their daughter cells to produce viable oocytes. The steroid hormone, ecdysone, is known to promote GSC self-renewal; however, due to lack of compatible genetic tools, potential autonomous roles in the …
-
The Neurogenic Capacity of Müller Glia and Synaptic Remodeling in the Mammalian Retina: Implications for Regenerative Therapies
Stem cell based therapies offer hope for the treatment of retinal disease. In the mammalian retina, Müller glia possess some stem cell-like characteristics. However, their capacity for neurogenesis remains limited. To identify factors influencing the neurogenic potential of Müller glia in vitro, a …
-
Identification of potential drug targets in glioblastoma using proteogenomic platforms
… (GBM) is a solid tumour of the central nervous system. To this date, it is the most aggressive primary brain tumour in adults, and few therapeutic solutions are available. This, in addition to the aggressiveness of the tumour, determine a low survival rate in patients. The World Health …
-
Tools for engineering multicellular systems through cell sorting and cell state detection
… seeks to expand on this blueprint and create cells with novel functions. The aim of this thesis is to provide methods that expands our ability to engineer and control multicellular systems by detecting and rewriting the cell state. We first develop a method that enables the creation of a …
Page 1 of 2