Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Stem cells --Transplantation"”.
-
Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy
… inflammation within the central nervous system (CNS) is coupled by ongoing neurodegeneration and demyelination. Cell transplantation is among the most promising therapeutic approaches in regenerative medicine, combining tissue trophic and immunomodulatory effects of the graft with its …
-
Olfactory progenitor cell transplantation into the mammalian inner ear
… optimal conditions for successful application of cells. The first part of this thesis describes the adaptation of the cochleovestibular structure harvested from P1 mouse pups for analysis of factors critical for the optimal implantation of stem cells in the inner ear. Results of these studies …
-
Exploring the effect of caregiver support on psychological distress in stem cell transplant patients
… social support on psychological distress in stem cell transplant recipients during the first 90 days post-transplant. Despite advancements in hematopoietic stem cell transplant (HSCT) techniques, recipients often experience severe psychological distress due to the invasive nature of the …
-
MICROFABRICATION OF TITANIUM DIBORIDE PATTERNED ON SILICON SUBSTRATES FOR MONO- AND CO-CULTURE OF ENDOTHELIAL AND MESENCHYMAL STEM CELLS
Transplantation of Islet of Langerhans is a treatment used in Diabetes Type I with an objective to introduce beta cells for secretion of insulin for controlling the glucose level in the body. Our project is focused on in vitro culturing of endothelial cells and mesenchymal cells on biocompatible …
-
Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
… study has shown that transplanted human neural stem cells (hNSCs) selectively migrate to the brain and induce behavioral recovery in mouse intracerebral hemorrhage (ICH) stroke model. However, many of the grafted hNSCs did not survive the transplantation, which may have reduced therapeutic …
-
Characterizing the Immunogenicity of Islet-like Cells derived from HLA-edited Human Pluripotent Stem Cells
… much hope for the therapeutic use of islet-like cells generated from human pluripotent stem cells, important challenges limit the clinical translation of this technology. In this thesis, I describe my efforts to address two of these challenges: the inability to control the composition of the …
-
Human neural stem cells: region-specific properties and prospects for cell therapy
Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural …
-
Developing a clinically applicable hydrogel for the treatment of liver disease
… the only cure for chronic liver failure is liver transplantation. However, the mismatch between patient demand and donor supply is widening. Regenerative medicine and tissue engineering including cell therapy and lab-grown mini-livers offer an exciting alternative to liver transplantation. …