Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1748 for “"Stem cells"”.
-
Potential Rest Targets In Neural Stem Cells and Glioblastoma-Derived Stem Cells
… are caused by self-renewing glioblastoma-derived stem cells (GSCs). At the current time, the mechanisms that regulate self-renewal and other oncogenic properties of GSCs remain unknown. Recently, we found transcriptional repressor REST maintains self-renewal in neural stem cells (NSCs) and in …
-
Regulation of Hematopoietic Stem Cells
… thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate new …
-
Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells
<p>Embryonic stem cells (ESCs) are cells that have unlimited capacity for selfrenewal and differentiation. These properties make ESCs a great cell source for application in regenerative medicine. When used for cell therapy, ESC-derived cells could be placed in a wounded area that is likely to be …
-
Cellular Mechanisms of Cancer Stem Cells
The file named "bhagwandinvikash.pdf" is the primary dissertation file. To access the supplemental video, click on the file named "3D_BLI_of_Pancreatic_Tumor.mpg".
-
United States stem cells research boundaries
… of researchers. We focus our investigation on stem cell research in the United States (US). Research in human developmental biology has led to the discovery of human stem cells. The science of stem cell therapies is about to enter a phase of research and development that could lead to …
-
Neural Stem Cells in Brain Tumor Development
… mouse models indicated a central role for neural stem cells and stem cell-like cancer cells in malignant astrocytoma formation. Using stereotactic viral cre-mediated approach, we demonstrate that targeting of tumor suppressor inactivating mutations in the subventricular zone (SVZ) where neural …
-
Molecular Characterization of Glioblastoma Cancer Stem Cells
… of GBM is believed to be sustained by cancer stem-like cell populations that are able to initiate and maintain tumors. Although CSCs represent only a small fraction of cells within a tumor, their high tumor-initiating capacity and therapeutic resistance is believed to drive tumorigenesis. …
-
Human embryonic stem cells for genotoxicity testing
… mammalian cell lines and primary explanted cells commonly used in vitro to analyze the genotoxic potential of various agents, often poorly reflect human physiology. Lack of standardization also limits use of primary explanted cells. Human embryonic stem cells (hESCs) have been validated as a …
-
DNA Damage responses in plant stem cells
… processes such as transposon movement. Plant stem cell populations in particular must be protected from genotoxicity, as they are the origin of all organs, together with the germline. In accordance with this premise, plant stem cells were found to be hypersensitive to Double Strand Breaks …
-
Targeting survival pathways in cancer stem cells
The discovery of tumor-initiating cells endowed with stem-like features, and therefore referred to as cancer stem cells (CSCs), has added a further level of complexity to the pathobiology of neoplastic diseases. This uncommon cellular subpopulation has been connected with tumor initiation, …
-
Nuclear Transfer With Porcine Embryonic Stem Cells
… of NT embryos constructed from porcine ES cells beyond the four-cell stage. However, enucleated zygotes supported development of NT embryos beyond the four-cell stage to the compact morula stage. These results provide preliminary evidence for in vitro development of NT embryos produced from …
-
Transdifferentiation of fibroblasts to neural stem cells
… indistinguishable from an embryonic stem (ES) cell. However, it is still unclear if transcription factors can completely convert the nucleus of a differentiated cell into that of a distantly related somatic cell type with complete transcriptional and epigenetic reprogramming …
-
Primitive Neural Stem Cells in the Mouse Brain
Neural stem cells (NSCs) reside in the tissue lining the lateral ventricles of the adult mouse brain. At the top of the hierarchy are primitive (p)NSCs that arise in advance of definitive (d)NSCs embryonically. After the discovery that pNSCs persist in the adult mouse brain, I sought out to …
-
The role of cancer stem cells in osteosarcoma
… OS cancers contain a small population of cancer stem cells (CSC) which initiate tumour growth. The cancer stem cell hypothesis describes cancers as a hierarchical population of heterogeneous cells. It has been proposed that CSC are at the base of this hierarchy and are responsible for the …
-
Endothelialization of Bypass Grafts Using Autologous Stem Cells
… done through pre-seeding with non-thrombogenic cells. Adipose-derived mesenchymal stem cells (ASCs) are good source of autologous stem cells for vascular differentiation, especially endothelial cells (ECs). In this work, we seeded ASCs onto fibroblast-remodeled fibrin tissues to create a …
-
Modeling Alzheimer's Disease in Induced Pluripotent Stem Cells
… utilized recent advances in induced pluripotent stem cell (iPSC) and genome editing technologies to investigate two separate AD disease mechanisms: tau spreading and Aβ production in familial AD (FAD) PSEN1 mutants. Using TALENs, we generated a transgenic donor iPSC line that harbors a transgene …
-
Mobilisation, Isolation and Coculture of Haematopoietic Stem Cells
Since decades, hematopoietic stem cell transplantation (HSCT) has become a well established treatment modality for hematological malignancies and non-malignant disorders. Autologous and allogeneic hematopoietic stem cells (HSCs) mobilized into the peripheral blood (PB) have been used as a preferred …
Page 1 of 88