Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Stem cell therapy"”.
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A Biomaterial-based Stem Cell Therapy for Retinal Regeneration
… or regenerate the retina with healthy cells to improve vision. Emerging therapies, in clinical trials, are investigating stem cell-derived photoreceptors injected, in a saline solution, into the subretinal space to replace dying cells caused by retinal degeneration. The principal …
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Mesenchymal stem cell therapy for the treatment of myocardial infarction
Mesenchymal stem cells (MSCs) are currently under investigation as repair agents in the preservation of cardiac function following myocardial infarction (MI). However concerns have emerged regarding the safety of acute intracoronary (IC) MSC delivery specifically related to mortality, …
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Immuno-suppressive hydrogels for stem cell therapy after traumatic brain injury
… pathways. This initial insult activates multiple cellular mechanisms that further propagate the tissue damage causing a secondary injury that exacerbates neurological deficits. This phase, known as the secondary injury, opens a therapeutic window in which neuroprotective treatments that …
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The Application of Mesenchymal Stem Cell therapy on Multiple System Atrophy
Since disease progression in multiple system atrophy(MSA) is much faster and no drug treatment consistently benefits MSA patients in the long-term, neuroprotective or regenerative strategies are inevitable in the management of MSA patients. We divided two group, MSC-treated(n＝11) and control …
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An analysis of consent with specific regard to stem cell therapy and research
This thesis argues that stem cells cannot be properly regulated when understood in terms of medical treatment only. This is due to the uncertain scope and untested efficacy of stem cell therapy which renders treatment applications tantamount to research involving human subjects. This thesis …
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Immune Mechanisms of Mesenchymal Stem Cell Therapy for Acute Graft versus Host Disease
… work was to investigate the role of Mesenchymal stem cells (MSC) in the modulation of immune responses, focusing on suppression and induction of immune tolerance. To date, MSC therapy has proved beneficial for the treatment of inflammatory and autoimmune diseases, such as acute Graft versus Host …
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PHOSPHODIESTERASE-5 INHIBITION: A NOVEL STRATEGY TO IMPROVE STEM CELL THERAPY IN THE HEART
<p>Several studies have shown cellular replacement therapy as a treatment strategy of myocardial infarction but results have been limited. Therefore, enhancing the therapeutic potential of stem cells injected into ischemic microenvironments by novel preconditioning (PC) techniques is critical for …
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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… recognized and attacked by the host immune system while the PNF is characterized as the loss of islet viability and function caused by non-immune reasons, such as the disruption of islet microvasculature during islet isolation and purification process, hypoxia in the core of islet grafts and …
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Development of a novel imaging system for cell therapy in the brain.
… clinical and experimental studies have evaluated stem cells as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. The identification of the location, migration and biodistribution …
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Novel Options for the Treatment of Corneal Disease
… transplantation (wound healing modulation & stem cell therapy) and procedures which aim to delay or eliminate the need for a corneal transplant (cornea crosslinking or CXL). Specifically, data analyses were performed to measure the efficacy of various cornea crosslinking protocols in patients …
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The Epicardium as the Conductor of Cardiovascular Cells in Cardiac Regeneration
Stem cell therapy for cardiac repair is a field of regenerative cardiovascular medicine that is emerging as a promising therapeutic alternative to heart transplantation in patients suffering from chronic heart failure. Although promising, challenges to cell therapy for cardiac repair remain, …
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Žūties ir išgyvenimo signalinių mechanizmų tyrimai suaugusio organizmo raumens kamieninių ląstelių diferenciacijos metu /
… study demonstrates that adult muscle-derived stem cells with unlimited proliferative potential in vitro are able to differentiate into myogenic, adipogenic, osteogenic and neurogenic lineages. Differences in susceptibility to apoptotic stimuli depending on cell differentiation status and …
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Dysregulation in polycystic ovary syndrome: mechanisms and therapeutic approaches
… New approaches under investigation include stem cell therapy, gene-targeted treatments, kisspeptin-based therapies, and interventions targeting the gut microbiome. While PCOS does not yet have a cure,scientific advancements are bringing the possibly of personalized, lasting treatments closer …
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Discovery of novel anti-inflammatory proteins inspired by bone marrow mesenchymal stem cell secretions
Bone marrow mesenchymal stem cells (MSCs) may soon become the first FDA-approved stem cell therapy for autoimmune and inflammatory disease. Our lab originally hypothesized that much of the therapeutic activity of MSCs may be attributed to molecules secreted by these cells. This thesis will test …
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PRE-CLINICAL MODELING OF CELL AND GENE THERAPY OF FANCONI ANEMIA
… of immunophenotype-defined hematopoietic stem and progenitor cells (HSPCs), the number of functional stem cells within the impaired HSPC population remains unknown. Additionally, it is unclear whether current gene therapy approaches, aimed at correcting FA hematological defects by gene …
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Smart Materials for Cartilage and Bone Tissue Engineering
… cartilage, and the limited number of progenitor cells, it is challenging for regeneration of cartilage defects. Furthermore, because of the distinct structure of cartilage and subchondral bone, stem cell-alone or biomaterial-alone based strategy might not be able to simultaneously fulfil the …
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Characterization of the cardiogenesis of embryonic stem cells
… as the leading cause of mortality worldwide. Stem cell therapy, aimed to restore contractility and proper vasculature, has gained considerable attention as an attractive therapeutic option. However, proper cell differentiation, survival and integration in an infarcted zone remain elusive. This …
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Disruption of Immunoregulatory Functions of Intestinal Mesenchymal Stromal Cells and their Progenitors in Inflammatory Bowel Disease
… (CMFs) are abundant innate immune cells in normal colonic mucosa that express Programmed Death-Ligands 1 & 2 (PD-L1/2) to promote immune tolerance. However, PD-L1 signaling is altered in IBD for as yet unknown reasons. Gremlin 1+ (Grem1) Mesenchymal Stromal progenitor Cells (MSCs) …
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Stem Cell and Biological Interventions to treat Allergic Airway Disease
… B. pertussis, BPZE1) or using a candidate cell therapy approach (mesenchymal stem cells, MSC). This work demonstrated that, in contrast to virulent B. pertussis, an attenuated, candidate vaccine strain of B. pertussis, BPZE1, did not enhance but rather reduced allergendriven airway …
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