Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Stem cell reprogramming"”.
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REGULATION OF TELOMERASE EXPRESSION IN STEM CELL REPROGRAMMING
… easily accessible source of patient-specific cells that will function for use in regenerative medicine. One promising source is the adult stem cell derived from adipose tissue (ASCs). Isolated from waste lipoaspiration, these cells could serve as a readily available source for the regeneration …
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Defining the essential regulators of naive human pluripotent stem cell reprogramming
Human pluripotent stem cells (PSCs) exist in two distinct states – naïve and primed, which are interconvertible. Naïve PSCs uniquely harbour several desirable properties that primed PSCs do not, including their ability to model human pre-implantation biology and developmentally-regulated epigenetic …
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Computational Systems Biology Analysis of Cell Reprogramming and Activation Dynamics
In the past two decades, molecular cell biology has transitioned from a traditional descriptive science into a quantitative science that systematically measures cellular dynamics on different levels of genome, transcriptome and proteome. Along with this transition emerges the interdisciplinary …
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Molecular mechanisms of Kruppel-like Factor 4
… and of the skin. Wnt signaling is implicated in stem cell renewal. Deregulation of Wnt/beta-catenin signaling is crucial early event in colorectal tumorigenesis. Earlier work in our lab demonstrated that Kruppel-like factor 4 (KLF4) interacts with beta-catenin in vivo, repressing Wnt signaling …
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NANOGP1 as a Model to Study the Consequences of Gene Duplications on Human Pluripotency and Development
… of pseudogenes in human naïve pluripotent stem cells (PSCs), I found that NANOGP1 is among the top 1% of the highest expressed pseudogenes. Because high expression levels of NANOG are crucial for maintaining human pluripotency, I hypothesised that a duplicated copy of this important …