Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Stem cell regulation"”.
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Mechanism of Spermatogonial Stem Cell Regulation by ETV2
… is the process through which male germ cells give rise to spermatozoa. Spermatogenesis is initiated from spermatogonial stem cells (SSCs) which self-renew or differentiate to give rise to differentiated progenies of germ cells. Hence understanding of SSC biology is essential to …
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Cellular and genetic mechanisms of new tissue production in the regenerating planarian Schmidtea mediterranea
… planarian heads, require both a source for new cellular material as well as mechanisms to specify, differentiate, and pattern the regenerate. The planarian Schmidtea mediterranea is a classic system for studies of regenerative biology in which proliferating cells known as "neoblasts" provide the …
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Modulation of the Hippocampal Neurogenic Program by the Circadian Clock Machinery and the small GTPase, Rasd1/ Dexras1
… is home to a limited pool of quiescent neural stem/ progenitor cells (QNPs). These cells respond to intrinsic and extrinsic physiological changes, embark on the neurogenesis program and give rise to glutamatergic granule neurons that populate the dentate gyrus (DG). In this thesis, I uncovered …
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Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
… factor, KLF4, plays a vital role in the regulation of lineage differentiation during development, as well as the maintenance of epithelial homeostasis in the intestine. KLF4 is predominantly expressed in the epithelial cells that are fully differentiated in normal intestine. In colorectal …
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Application and Development of Advanced Genetic Tools to Study Adult Stem Cells
… of Advanced Genetic Tools to Study Adult Stem Cells By: Amanda Andersson Rolf In adult mammals, the gastrointestinal (GI) epithelium exhibits the highest turnover rate among the endodermal tissues. The harsh luminal environment of the GI tract necessitates replenishment of epithelial cells …
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Translational mechanisms of stem cell fate regulation in epidermal oncogene tolerance
… we find that oncogenic RAS-induced progenitor cell hyperproliferation is coordinated with differentiation to restrain aberrant growth and preserve epidermal development. We uncover a novel translation mechanism mediated by initiation factor eIF2B5 that co-regulates RAS proliferation and …