Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Stem cell models"”.
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Deconvoluting genetic variants associated with aortic disease using stem cell models
… This study aimed to utilise induced pluripotent stem cell (iPSC) models of TAD to analyse genetic variants from the 100,000 Genomes Project by determining causality, disease mechanisms and identifying drug targets. We focused on three Tier One variants, protein truncating in known …
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Comparative studies of brain developmental timing and progression using 3D stem cell models
… We used self-organising brain organoid models, derived from stem cells of different relevant species to establish paradigms for comparative studies in brain development, and understand aspects of human specific brain development in vitro. In order to make fair comparisons between brain …
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Human induced pluripotent stem cell models of Rett Syndrome reveal deficits in early cortical development
… neurons with the use of induced pluripotent stem cells (iPSCs) derived from RTT patient skin samples. We generated a variety of monolayer and 3D neuronal models and found that RTT phenotypes are present at the earliest stages of brain development including neuroepithelial expansion, neural …
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Integrin signalling in pluripotent cells acts as a gatekeeper of mouse germline entry
Primordial germ cells (PGCs) are the undifferentiated precursors of gametes and the sole mechanism by which genetic information is transmitted across generations through the germline. They appear at the proximal posterior region of the mouse embryo, where the somatic germ layers begin to emerge and …
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Cells of the Developing Human Heart and Great Vessels
… heart and the great vessels comprise various cell types that collectively support the heart’s homeostasis. Single-cell genomics has expanded our knowledge of the heart’s cellular heterogeneity. By gaining a deeper understanding of its cellular makeup, we can uncover how these cells converge to …
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WNT signalling in the patterning of human gastruloids
… this date. The derivation of human embryonic stem cells (hESCs) has opened up numerous opportunities for studying early cell fate decisions and signals involved in this process. In particular, these cells have enabled the development of embryo models that allow the exploration of various …
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Microelectrode Array Modeling of Genetic Neurological Disorders in the Era of Next Generation Sequencing
… However, the development of appropriate systems to functionally interpret variants and identify pathogenic mechanisms has lagged behind. Understanding pathogenic mechanisms is crucial to the development of targeted therapeutics. Therefore, the main challenge to translating genetic findings …