Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Stem cell marker"”.
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DELINEATING REGULATORY PATHWAYS OF NOVEL CANCER STEM CELL MARKER, DCLK1-S, FOR TARGETING COLON CANCER STEM CELLS
… consequences for the patient and society. Cancer stem cells are believed to be resistant to conventional treatments resulting in relapse of the disease. Targeting cancer stem cells in addition to conventional therapy may result in better outcomes for patients. Colon cancer stem cells express …
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Expression of Aldehyde dehydrogenase (ALDH) in the breast stem cell line D492 and relations to stem cell properties
… are enzymes expressed in both normal and cancer stem cells (CSC). CSCs are hypothesized to arise from normal stem cells and acquire a malignant phenotype through series of genetic mutations. Current therapies often fail to eradicate CSCs causing metastatic relapse. Further characterization of …
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Isolation, Culture and Cryopreservaion of Neural Stem Cell
… intermediated filament proteins and a well-known stem cell marker in the neural lineage. The nestin gene consists of four exons and three introns. It has been known that the nestin transgene containing the second intron is sufficient to direct tissue specific expression of the nestin gene in …
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Activity-based sensors for reactive aldehydes and their corresponding enzymatic machinery
… active enzyme. Activity-based sensors are also excellent sensors for reactive small molecules with unique chemical reactivity. Here, we report the development and/or progress on activity-based sensors for reactive biological aldehydes and the enzymatic machinery tasked with aldehyde metabolism. We …
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Biology of adult human normal and leukaemia CD133+ stem cells
Recently, CD133 has been used extensively as a marker for identification of stem cells from human normal and malignant tissues. Human normal CD 133+ stem cells are capable of multilineage in vitro and in vivo differentiation providing a novel source of stem cells for regenerative therapy, whereas, …
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The characterisation of Pax3 expressant cells in adult peripheral nerve
… while knowledge of its complex function in cells of adult tissue continues to unfold. Across a variety of adult tissue lineages, the role of Pax3 is principally linked to maintenance of the tissue’s resident stem and progenitor cell population. In adult peripheral nerves, Pax3 is reported to …
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Outlining a balance-point model of homeostasis in the small intestine of broiler chickens
… that in two of the four groups the expression of stem cell gene Olfactomedin 4 was absent from the crypt though other functional genes were found to still be expressed there. Chapter 3 characterized intestinal gene expression following a single challenge of Eimeria acervulina in broiler chickens. …
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Duchenne muscular dystrophy and extraocular muscle: a potential sparing mechanism with therapeutic implications.
… the role of extraocular muscle (EOM) progenitor cells in sparing the muscles from pathology associated with Duchenne Muscular Dystrophy (DMD). Mouse models of muscular dystrophy and wild type mice were analyzed by flow cytometry and cell culture for the size, heterogeneity and functional …
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Sustained Depolarization of the Resting Membrane Potential Regulates Muscle Progenitor Cell Growth and Maintains Stem Cell Identity in vitro
… the myogenic properties of muscle progenitor cells (MPCs) during in vitro expansion for stem cell therapies and tissue engineering applications. Controlling cell fate for biomedical interventions will require insight on all aspects that influence cellular properties. The resting membrane …
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Expression and Putative Functions of Fibroblast Growth Factor 10 (Fgf10) in Developing and Adult Skeletal Muscles
… myonuclei expresses this satellite stem cell marker. To delineate the function of Fgf10, I examined the limbs of newborn Pax3- Cre::Fgf10(flox/-) double transgenic mice, and I discovered that myofiber growth was impaired in Fgf10-expressing muscles. Moreover, the distal myofiber …
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Predicting molecular markers of development and regeneration through integrative analysis of high-throughput genomics data
… proteins is often used to identify particular cell types, developmental states, or pathogenic states to which they are unique. In this context, such transcripts and proteins are termed molecular markers. Molecular markers are indispensable in many facets of scientific research and can …
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Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
… is predominantly expressed in the epithelial cells that are fully differentiated in normal intestine. In colorectal cancer, KLF4 was identified as a tumor suppressor; it is also a stem cell factor that along with other factors can induce pluripotent stem cells. KLF4 knockout mice demonstrate …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
… are mostly benign tumours of the nervous system that currently have no clinically approved treatments apart from surgical resection. The tumour suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. The Hippo pathway is …
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Hepatitis C Virus-Induced Hepatocellular Carcinoma: Cancer Stem Cell and Gene Therapy
… chronic hepatitis cirrhosis, steatosis and hepatocellular carcinoma (HCC) worldwide. Although current FDA-approved drugs are partially effective in the treatment of HCV, methods for cure and vaccine against the virus are still awaited. My thesis work presented here is focused on finding mechanism …
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Modeling Epithelial Ovarian Cancer In The Mouse
… (MPM/SHG) imaging are well suited for studies of cell motility in vivo and can complement pathological characterization EOC by allowing optical biopsies of native human and mouse tissues at resolution comparable to that of routinely processed histological sections. We have also shown the …
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Stemness status in differentiated and undifferentiated glioma cells
Undifferentiated cancer stem cells (CSCs) with their unique potential of self-renewal and multi-lineage differentiation fuel tumour growth and relapse. Efficacy of glioma therapy can be considerably improved if the target is focused towards successful identification and elimination of CSCs. The aim …
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Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture
… but do not modify progression. Mesenchymal stem cells (MSCs) have multi-modal properties but are ineffective in ameliorating equine OA. However, anti-inflammatory activities of bone marrow derived MSCs (BMSCs) are enhanced by three-dimensional spheroid culture so equine BMSC (eBMSC) …
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… E6 proteins act through interaction with host cellular proteins, while little is known about the cellular interacting partners to low-risk E6 proteins. Here we used GST-pulldown coupled with mass spectrometry to identify potential cellular host proteins to E6 proteins from low-risk types 6 and …
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… E6 proteins act through interaction with host cellular proteins, while little is known about the cellular interacting partners to low-risk E6 proteins. Here we used GST-pulldown coupled with mass spectrometry to identify potential cellular host proteins to E6 proteins from low-risk types 6 and …
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