Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Stem cell factor"”.
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ADAM10: a Novel Regulator of Mast Cell Function and Activation
… description of the role ADAM10 plays on mast cells. ADAM10 is abundantly expressed on mast cells both in vitro and in vivo. Its expression is inhibited by IL-10, a suppressive cytokine. siRNA depletion of ADAM10 on bone marrow-derived mast cells (BMMC) caused decreased IL-6 production …
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Sphingosine-1-phosphate in mast cell-mediated allergic responses
Mast cells play a critical role in both acute and chronic inflammation and mature in peripheral tissues from bone marrow-derived progenitors that circulate in the blood as immature precursors. Mast cell progenitors are likely to encounter the serum-borne bioactive sphingolipid metabolite, …
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The role of fibrolast-derived cytokines on melasma
… radiation, sex hormone, and genetic predisposing factors, however, the exact mechanism of pathogenesis is not clearly demonstrated. Previous studies have been bringing focus into the pigmentation formed by interaction between keratinocytes and melanocytes. Recently, it was reported that dermal …
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Ein neuer und ungewöhnlicher Signalweg erlaubt physiologischen Konzentrationen von Erythropoetin mitogene Kinasen in primären erythroiden Vorläuferzellen zu aktivieren
… zur Aktivierung der mitogenen Kinasen („extracellular signal-regulated kinases“ (Erks) und „mitogen-activated protein kinase/Erk-activating kinases“ (MEKs)). Der Mechanismus der Aktivierung war bisher unklar. Mehrere wissenschaftliche Gruppen haben zudem unerwartet herausgefunden, dass eine …
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Characterisation of cytokine secretion in malignant gliomas
Cytokines are proteins produced by cells of the immune system. The working hypothesis of the thesis is to show that the lymphocytes and glial cells in Glioblastoma Multiformae patients have an altered pattern of secretion of cytokines compared with low-grade and non-cancerous patients. Lymphocyte …
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Soluble C-Kit Receptor Level May Be a Serological Marker for Predicting the Extent of Upper and Lower Airway Inflammation
… inflammation composing activated mast cells and eosinophils. Mast cell development and survival is dependent on the Kit-mediated activation and this stem cell factor (SCF)/c-kit pathway leads to eosinophil infiltration. We investigated whether SCF/c-kit pathway induced inflammation is …
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Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
The zinc finger protein and transcription factor, KLF4, plays a vital role in the regulation of lineage differentiation during development, as well as the maintenance of epithelial homeostasis in the intestine. KLF4 is predominantly expressed in the epithelial cells that are fully differentiated in …
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The Immunohistological Features of Acquired Bilateral Nevus of Ota-like Macules: Comparison with Melasma and Nevus of Ota
… and immunohistological findings of NKI/beteb, stem cell factor (SCF), c-kit, factor VIIIa-related antigen and vascular endothelial growth factor (VEGF) were examined and quantified by image analysis. RESULTS: In ABNOM, the amount of lesional dermal pigmentation and melanocytes were increased …
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Extrinsic regulation of fate choice in mouse haematopoietic stem cells
… of fate choice in mouse haematopoietic stem cells The mechanisms regulating stem cell self-renewal, proliferation, and differentiation are still not fully understood. Improving our knowledge of these processes will not only provide greater insight into stem cell biology but will also …
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… to expression of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with pre-B ALL in clinical cases, murine models produce myeloid or T-lymphoid leukemias, which are not representative of the clinical disease. In this work, we have advanced progress …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… specificity and function of natural killer: NK) cells, their differentiation has not been fully elucidated. Previous studies of thymocyte development <italic> in vitro</italic> indicate that double negative: CD4<super>&minus</super>CD8<super>&minus</super>, DN) thymocytes can develop into cells …
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Regulatory Proteins in Progenitors and Differentiated Cells of the Human Prostate
… therapy. Our understanding of PC, including cell source and mechanisms in initiation and progression of PC, is impeded by our lack of knowledge regarding cell regulation, self-renewal, and cellular differentiation mechanisms in the prostate gland. In this study, we aimed to investigate these …
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The Study of Serial Histochemical Changes in Laser-related Post-inflammatory Hyperpigmentation
… proteins and paracrine melanogenic factors are regulated by laser surgery, time-sequential immunohistochemical studies were performed with Q-switched alexandrite laser (QSL)-irradiated skin of four healthy subjects. Skin biopsies were performed at baseline first and then immediately, …
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Transcriptional profile of c-kit positive cardiac stem-progenitor cells (c-kitpos eCSCs) isolated from the four chambers of the adult human heart
… a population of resident (endogenous) cardiac stem cells (eCSCs). They express the stem cell factor receptor c-kit, are distributed throughout the myocardium, are clonogenic, self-renewing and multi-potent, in that they differentiate into the 3 main cardiac lineages; cardiomyocytes, smooth …
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Chemotactic behavior of immature and mature blood cells in response to the cytokines: SDF-1, steel factor, CKbeta-11 and SLC
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Identification of Epo-independent red cell progenitors : the E-cad+ progenitors
… notwendig. Den Wachstumsfaktoren stem cell factor (SCF) und Erythropoietin (Epo) fällt dabei eine entscheidende Rolle zu. Unter ihrem synergistischen Einfluß lassen sich Epo-abhängige Zellpopulationen, die sich aus BFU-E und CFU-E Typ Zellen zusammensetzen, ausreichend …
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Investigation on the Molecular Mechanism of Photorejuvenation in Photodynamic Therapy
… type Iα through prolonged activation of extracellular signal–regulated kinase (ERK). Increased MMP-3 may induce breakage of old collagen and allow new collagen synthesis. PURPOSE: In this study, I investigated molecular mechanism of photorejuvenation after PDT focused on interaction between …
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Oncogene-induced reprogramming of heterotypic cellular interactions
… signalling hub that orchestrates fundamental cellular decisions such as cell survival, proliferation and differentiation. Activating mutations in KRAS are among the most frequently occurring oncogenic mutations driving cancers that are particularly refractory to therapy (e.g., colorectal, …
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The Role of Platelets In Ovarian Carcinoma
… storage pools of angiogenic and oncogenic growth factors in the human body. The observation that thrombocytosis (platelet count >450,000/uL) occurs in patients with solid malignancies was made over 100 years ago. However, the clinical and biological implications as well as the underlying mechanism …
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Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
… and arises from early sympathetic nervous system (SNS) cells arrested in their development. Generally, a low tumor cell differentiation correlates to poor prognosis. Solid tumors, like neuroblastoma, frequently contain regions of oxygen deficiency ? hypoxia ? caused by a high rate of cellular …