Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Stem cell biology"”.
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Transcriptional regulators in stem cell biology
Adult stem cells support tissue regeneration by both self-renewing and differentiating into specialized cell types. Analogous self-renewal and differentiation processes enable cancer stem cells to promote tumorigenesis. Transcriptional modulation, enacted by proteins including epigenetic regulators …
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The Effect of Caffeine and Ethanol on Flatworm Regeneration.
… used as a model to investigate regeneration and stem cell biology for over a century. Chemicals, temperature, and seasonal factors can influence planarian regeneration. Caffeine and ethanol are two widely used drugs and their effect on flatworm regeneration was evaluated in this experiment. …
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Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond
… Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. The compound promotes the initial stages of the proliferative regeneration of hair cells, a process thought to be permanently suppressed in the adult …
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Illuminating Clonal Dynamics: Development and Use of a High-Throughput Cellular Barcoding System to Track Clonal Evolution
… important in understanding aspects of cancer and stem cell biology. Attempts to track the contributions of individual cells to the clonality of large homogenous populations, however, have been constrained by limitations in sensitivity and complexity. We have created an efficient and high …
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COMPARISON OF EQUINE BONE MARROW-, UMBILICAL CORD MATRIX-, AMNIOTIC FLUID- AND TENDON-DERIVED PROGENITOR CELLS
Mesenchymal stem cells have been recently investigated for their potential use in regenerative medicine. It has been suggested that there may be a stem cell population within both umbilical cord matrix and amniotic fluid. However, little knowledge exists about the characteristics of these …
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APPLICATIONS OF MICROARRAYS AND STEM CELLS FOR REGENERATIVE MEDICINE
Stem cells are viewed as a potential resource for cell-based therapy and regenerative medicine. Understanding the genes that govern the special properties of stem cells has implications for both stem cell biology and regenerative medicine. This information will ensure the quality of the cells, the …
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Modularity in Somatic Cell Reprogramming
Reprogramming relies on the concept that cellular fate is plastic, and therefore a considerable effort has been made to develop molecular strategies that reset the epigenome to achieve distinct cell fates, including stem cells. Deriving induced pluripotent stem (iPS) cells has thus emerged as a …
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The Role of p66Shc in Stem Cells: Signalling, Identity and Apoptosis
… (RTKs) to downstream signalling, thereby shaping cell fate decisions. While the canonical isoforms p52Shc and p46Shc act as Ras–MAPK transducers, the longer p66Shc isoform harbours an additional CH2 domain that confers distinct regulatory properties. Despite long-standing associations with …
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Modeling the Effects of Mechanical Loading on Hypertrophic Cardiomyopathy Pathogenesis in Human Induced Pluripotent Stem Cell derived Micro Heart Muscle
… Promising approaches in tissue engineering and stem cell biology have significantly improved the structural and functional maturity of the engineered heart tissue derived from human induced pluripotent stem cells, which can be served as a complementary method to traditional mouse models. …
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P120-Catenin Regulates Rest and Corest, and Modulates Mouse Embryonic Stem Cell Differentiation
… studied to determine their contributions to stem cell biology, but less is known about p120-catenin in the nuclear compartment. P120 is developmentally required as a consequence of its biochemical and functional interactions with cadherins, small-GTPases and transcriptional regulators. We …
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Establishment of the epigenetic landscape in mammalian embryonic stem cells
… phenomena has the potential to enrich both stem cell biology and therapeutics, as well as offer insight into various pathologies. While the enzymatic machinery responsible for these transitions is well known, it is their localization to specific genomic regions that controls cell fate, and …
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Elucidating the Role of BMI1 in Lung and Colon Tumor Maintenance and Progression
… tumor tissues, there exists a subpopulation of cells, termed cancer stem cells (CSCs), with the ability to initiate and support tumor growth, promote metastatic spreading, and drive relapse following chemoradiotherapy. Given the high tumorigenic potential of these cells, there is strong interest …
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Intercellular Feedback in Hematopoiesis
Despite the importance of inter-cellular (between cell) communication networks in regulating homeostasis in multicellular organisms, very little is known about their topology, dynamics, or functional significance. Inter-cellular communication networks are particularly relevant in stem cell biology, …
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The Importance of Glucose Transport in Reproductive Events
… by Katie Lynn Adastra Doctor of Philosophy in Biology and Biomedical Sciences Developmental, Regenerative and Stem Cell Biology Washington University in St. Louis, 2012 Professor Kelle H. Moley, Chairperson Successful pregnancy outcome is contingent on a number of factors, the earliest of which …
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Coordinating Stem Cell Behavior in the Hair Follicle
<p>Tissue stem cells perform important functions throughout an organism's life. They generate new cells to replenish cells that are lost during normal wear and tear or in response to acute injury. Remarkably, hair follicles naturally undergo repetitive cycles of regeneration and degeneration, a …
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Investigating the role of NADPH oxidase 4 (NOX4) in differentiation and function of induced pluripotent stem cell–derived endothelial cells
Induced pluripotent stem cell-derived endothelial cells (iPS-ECs) hold clear potential for therapeutic angiogenesis in ischaemic diseases, although many challenges remain such as enrichment and expansion of homogenous, mature, highly proliferative and functional ECs. It is well established that …
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Investigating the effects of Wnt/β-catenin Signalling on Melanoma Cell Metabolism and Mitochondrial Dynamics
… play pivotal roles in embryonic development, stem cell biology and a number of disease states including cancer. Most Wnts signal through a pathway that results in the stabilisation of an intracellular signalling molecule called β-catenin. In melanoma cells, Wnt/β-catenin signalling has been …
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The Role of Cell Communication and 3D Cell-Matrix Environment in a Stem Cell-Based Tissue Engineering Strategy for Bone Repair
The use of stem cells for the repair of bone and cartilage is a primary research interest in modern tissue engineering strategies. The goal of this doctoral thesis was to investigate the role of cell communication and mechanical stimulation in a 3D tissue engineered construct, and to determine …
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Identification of pluripotent stem cells and characterization of glia in the planarian Schmidtea mediterranea
… Schmidtea mediterranea has emerged as a model system for the study of stem cell biology, tissue specification, and axis formation. Many aspects of the regenerative machinery have yet to be characterized. Although it is known that neoblasts, the population of all proliferative cells in the adult …
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The Impact of Chronic Morphine on Adult Hippocampal Progenitor Cells and the Neurogenic Niche
… It is unclear if morphine causes alterations in cell cycle progression, progenitor cell maturation, or indirectly inhibits progenitor cells by altering the hippocampal neurogenic niche. I first examined a time course of morphine's effect on the progenitor cell cycle, cell death and immature SGZ …
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