Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Stem Cell Microenvironment"”.
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Cell patterning technology for controlling the stem cell microenvironment
Embryonic stem cells serve as powerful models for the study of development and disease and hold enormous potential for future therapeutics. Yet, over two decades after mouse embryonic stem cells (mESCs) were first isolated, there is still little known about the role of cell-cell signaling in …
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Microfluidic perfusion culture for controlling the stem cell microenvironment
In multicellular organisms, cells do not exist in isolation but communicate with other cells via extracellular signaling molecules, many of which diffuse into the microenvironment. More than most cell types, embryonic stem cells (ESCs) are critically sensitive to their microenvironment, which plays …
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Optimizing alginate-chitosan microcapsules using co-axial air flow method as 3d stem cell microenvironment
Microencapsulation of cells is gaining popular interest in the field of biomedical engineering because it provides a more effective 3D scaffold that can mimic the cell microenvironment. The benefits of using microcapsules are biocompatibility, biodegradability, nontoxicity, and formation under mild …
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Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
<p>Squamous cell carcinomas (SCCs) are triggered by marked elevation of RAS/MAPK signaling and progression from benign papilloma to invasive malignancy. A subset of tumor-initiating basal progenitors, the cancer stem cells, obtain increased resistance to chemo and immunotherapy along this path. …
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The Role of Gata3 in Blood Stem Cell Emergence
The first definitive haematopoietic stem cells (HSCs) produced during embryonic development are generated from a specialised subset of endothelial cells known as haemogenic endothelium. Recently, it was reported that Gata3 plays a dual role in the development of sympathetic nervous system and …
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Roles for cell surface glycans in guiding human pluripotent stem cell fate
Cell-surface polysaccharides are a fundamental component of the stem cell microenvironment. They are known to modulate developmental signals- critical for pluripotency and differentiation. Nevertheless, the architecture of the cellular glycocalyx and how these structures direct the fate of human …
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Single-cell analysis of hematopoietic cell fate on niche-mimetic platforms using Raman microspectroscopy
… achieve controlled and reproducible expansion of stem cells ex vivo. Hematopoietic stem cells (HSCs) are the best-studied class of tissue-restricted stem cells and their microenvironment in vivo has also been the subject of considerable research. Although a host of cellular, molecular and physical …
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Stem cell matrix and cartilage regeneration
… due to its limited healing capacity. Current cell-based therapy using autologous chondrocyte implantation has been developed for decades and promising results have been observed in clinic. However, the shortage of autologous chondrocytes and their uncertain long-term effectiveness have led …
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Development of single-cell Raman spectroscopy for noninvasively screening the differentiation of living stem and progenitor cells in biomaterial platforms for 2D and 3D cell culture
Stem and progenitor cells' capabilities to self-renew, differentiate, and proliferate within their native tissue made them the subject of ongoing studies to understand the mechanisms of such processes and their potential use as therapeutics. Regenerative medicine encompasses the idea of treating …