Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Statin use"”.
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Association of blood lipids, atherosclerosis and statin use with dementia after stroke
… suffer more cardiovascular comorbidities. Statins have been recommended for secondary prevention in stroke patients, but it is unclear whether they have any cognitive effects separate from reducing risk of vascular events. Aim: To triangulate the potential roles of major blood lipids, …
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Protective Effect of Statin Use in the Progression of Dry to Exudative Age-Related Macular Degeneration
… macular degeneration (ARMD) is a leading cause of irreversible blindness in the industrialized world. Studies suggest that HMG CoA reductase inhibitors (statins) might slow the progression of dry ARMD to the exudative stage. We set out to determine if statin use reduces the risk of …
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Impact of Adiposity Status on the Association of Regular Statin Use and Increased Number of Aberrant Crypt Foci
… studies consistently show a preventive role of statin use in colon cancer development, evidence from human studies is conflicting with recent reports suggesting an increased risk of aberrant crypt foci and adenoma. We hypothesize that insufficient control of confounding due to indication bias …
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Chemoprevention in Kidney Cancer
… of three studies that explore the role of statins in kidney cancer. Furthermore, I evaluate the potential for different interpretations from the same data depending on the method of classifying medication use. Methods: The first study was a population-based case-control study evaluating the …
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The economics of a new health technology: an evaluation of the impact of statins on lifestyle behaviors
Background: Heart disease has been the leading cause of death in the United States since 1921, and although death rates have declined since their peak in the 1960s, it remains a significant burden to the population's health. For most of the second half of the 20th century, changes in …
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Cardiovascular Disease: Prevention and Management
… of morbidity and mortality in the United States. Statins, or HMG-CoA Reductase Inhibitors, are efficacious in reducing major arterial vascular events and also may decrease risk of venous vascular events (venous thromboembolism) in women taking hormone therapy (HT).1–3 However, these drugs have …
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Statins and Risk of Alzheimer Disease: A Systematic Review and Meta-Analysis
… of this research was to assess the effects of statins in the prevention of Alzheimer disease.</p><p>Methods: A systematic review of MEDLINE (PubMed) was performed to identify all available published prospective studies that evaluated the effect of statin treatment on the incidence of Alzheimer …
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Effet des statines sur les maladies cardiovasculaires chez les personnes âgées de 75 ans et plus
… complications. According to Canadian guidelines statins are recommended for the prevention of cardiovascular diseases. However, the effects of statins in preventing cardiovascular events in people aged 75 and over remain unclear. In addition, this population is often absent or underrepresented in …
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DNA Methylation: Methods and Analyses
… so advances are needed in the methodologies used to analyse such data. The first part of this thesis focuses on the development of tools that can be used for the analysis of DNA methylation microarray data. Firstly I develop a wide range of tools that can be used to quality control data. …
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The Epidemiology and Management of Ischaemic Heart Disease in New Zealand: A Series of National Routine Health Data-Linkage Studies
… the first three studies investigated long-term statin use, acute revascularisation and case fatality in people hospitalised with acute coronary syndromes (ACS). The latter five studies were focused on all hospitalised and fatal IHD, examining pre-hospital IHD case fatality and contemporary …
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Beta-blocker therapy in the era of primary percutaneous intervention for ST elevation myocardial infarction
… non betablocker groups (N=303) according to its use at discharge. Mean follow up month was 54±30 months. Primary end point was all-cause death and secondary end point was major adverse cardiac event (MACE; all-cause death, recurrent MI, target vessel revascularization). RESULTS: The beta-blocker …
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Farmacijos specialistų žinios ir požiūris į gydymo statinais naudą ir jų sukeliamą nepageidaujamą poveikį /
… and knowledge of pharmacy specialists about the statins. Objectives. 1. To evaluate the knowledge of pharmacy specialists about the benefits and risks of statin use. 2. To evaluate the knowledge of pharmacy specialists about potential interactions of statins with other medications. 3. To …
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The impact of high and intermittent-high glucose on ROS generation and bioenergetic metabolism in vascular endothelial cells
… with diabetes – an effect that was augmented by statin use.<br/>In conclusion, it is apparent that high glucose concentrations, rather than intermittent periods of high/low glucose, are responsible for increased superoxide production in HUVECs. Furthermore, treatment with high glucose within the …
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From Theory to Practice: Improving Causal Conclusions from Healthcare Data
… study, built upon previous research on statin use and atherosclerotic cardiovascular disease (ASCVD) incidence, we examine how including extraneous covariates---a likely risk when researchers over-adjust to mitigate concerns about unmeasured confounding---may degrade estimator …
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Epidemiological investigations of liver cancer: biomarkers, reproductive factors and modifiable risk factors:
Liver cancer is one of the leading causes of deaths in many countries around the world therefore identifying new risk factors for liver cancer is a priority. The aim of this thesis was to investigate new risk factors for liver cancer and add new insights to previously identified liver cancer risk …
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Ascertainment, prediction and implications of dementia diagnosis in a study of 'healthy' cognitive ageing: the Lothian Birth Cohort 1921
… of dementia in earlier old age. A history of statin-use was also observed to increase risk for dementia (OR: 3.39, 95% CI: 1.04, 11.02), while increased height reduced the risk for dementia (OR: 0.72, 95% CI: 0.55, 0.95). Overall, the findings suggested that the risk factor profile for …