Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Stathmin"”.
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Untersuchungen zur Rolle des Phosphoproteins Stathmin in Listeria monocytogenes-infizierten Säugerzellen und Molekulare Charakterisierung der listeriellen Zweikomponetensysteme
… Proteine konnte das zelluläre Phosphoprotein Stathmin identifiziert werden. Dieses Protein bindet an Untereinheiten des Tubulins und destabilisiert dadurch Mikrotubuli (MT). Es wird durch Phosphorylierung von vier spezifischen Serinresten in seiner MT-destabilisierenden Aktivität reguliert. Da …
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Interaktion des Proteins ActA von Listeria monocytogenes mit dem Wirtszellprotein LaXp180
… LaXp180 ist ein putativer Bindungspartner von Stathmin, einem 19 kDa Phosphoprotein, das die Mikrotubuli-Dynamik reguliert. Über Immunfluoreszenz konnte gezeigt werden, daß auch Stathmin mit intrazellulären, ActA-exprimierenden L. monocytogenes kolokalisiert.
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Investigations into novel signalling pathways in the response to viral and bacterial infections
… of two proteins, the microtubule regulator stathmin 1 and the protein phosphatase PPP1Cα led to a significant decrease in TLR4 mediated IL-6 production. Thus the current work has indicated novel roles for a number of proteins in the host response to pathogen challenge. TRAM is required for …
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Control of Chromosome Segregation by the Aurora B Complex
… and the microtubule destabilizing protein Op18/Stathmin. Chromatin-mediated CPC activation and spindle assembly require Dasra protein-dependent chromatin binding by the CPC, but this function of Dasra proteins can be bypassed by adding anti-Incenp antibodies, which autonomously stimulate Aurora …
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Mechanisms and consequences of resistance to PRMT5 Inhibition
… We found that this taxane sensitivity required stathmin 2 (STMN2), a microtubule regulator that is specifically expressed in the resistant state. Remarkably, Stmn2 was also required for the establishment and maintenance of resistance to PRMT5 inhibition. Analysis of TCGA patient data showed that …
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The development of an in vivo model to study the biology and treatment of childhood acute lymphoblastic leukaemia (ALL)
… parental xenografts. Decreased expression of stathmin and increased polymerised tubulin were observed in vincristine resistant sub-lines, suggesting a possible mechanism of counteracting the depolymerising effects of vincristine. In summary, this study has shown that primary ALL cells engraft …
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Serial Analysis of Gene Expression of Rat Liver Regeneration by Oval Hepatic Stem Cells
… Cyclin D1; Zytoskelett-assotiierte Proteine wie Stathmin 1 und E-Tropomodulin; Signaltransduktion triggernde Gene wie CDC151 und Lipopolysaccharid bindendes Protein; Transportergene wie Na+/Pi-Kotransporter 4, Phosphatidylcholin Transferprotein und ATPase H+ 34 kDa Lysosomaltransporter; …
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Chronic activation and downstream mechanisms of programmed axon death
… NMNAT2 and another axon-protective protein, Stathmin-2, it becomes evident that the proteins mediate their effects on axon maintenance through distinct pathways. Regarding mechanisms downstream of SARM1 activation, the data in this thesis support that primary neurons are able to survive with …
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Is my eye okay with OK lens?: comparative in vitro study depicting the effects of Orthokeratology (OK) lens treatment on the physiology of human corneal epithelial cells
… – annexin A3, pyridoxal kinase, peroxiredoxin-2, stathmin isoform A and heat shock protein 90-α, whose specific levels changed during treatment relative to the control, whilst 34 unidentified proteins were found to be up-regulated in specific expression and 27 unidentified proteins were found to …
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Targeting PRMT5 impairs cancer proliferation through splicing but promotes state shifts that enable resistance and disease progression
… and collateral paclitaxel sensitivity depend on stathmin 2 (Stmn2), a microtubule regulator specifically expressed in resistant cells. This observation has direct clinical relevance, as co-treatment with PRMT5i and taxanes was highly effective at killing multiple cancer cell lines, and suppressed …
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Proteomic investigation of the molecular targets of mycophenolic acid in human cells
… 5 proteins were down-regulated (protein SET, stathmin, 40S ribosomal protein S12, histone H2B type 1 A, and histone H2B type 1-C/E/F/G/I). Functional annotation tool analysis showed that MPA modulated proteins were mainly involved in the cytoskeleton (26%), chromatin structure/dynamics (17%), …