Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 51 for “"Stat5"”.
-
STAT5 regulierte differentielle Genexpression in prä-B-leukämischen Zellen
… Arbeit sollte die Bedeutung der konstitutiven STAT5 Aktivierung im Prozeß der Leukämogenese untersucht werden. Primär wurde ein Zellmodell etabliert und charakterisiert, das aus den Prä-B-Zellen BaMRS und BaMR aufgebaut wurde. Hierzu wurden IL-10 Rezeptor transfizierte BaF3 Prä-B-Zellen in …
-
Ube4B Levels Determine The Efficacy of Egfr and Stat5 Inhibitors In Treatment Resistant Neuroblastoma
… were altered, including an increase in EGFR and STAT5a levels. We observed that treatment with Cetuximab, a therapeutic antibody targeting the EGFR, significantly inhibited the proliferation of neuroblastoma cells depleted of UBE4B. Addition of a STAT5 inhibitor potentiated the Cetuximab-induced …
-
Sumo-Specific Protease 1 Controls Lymphoid Development Through Regulation of Sumoylation/Acetylation Switch In Stat5
… functions of SENPs are poorly understood. STAT5 (Signal Transducer and Activator of Transcription 5) plays a critical role in the development of lymphoid cells. However, it is not known whether STAT5 is regulated by the SUMOylation pathway. Here, we showed that SUMOylated STAT5 is …
-
Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
… Interestingly, phosphorylation and activation of STAT5, a transcription factor that mediates PRL signaling, was absent in Cuzd1-null mammary tissue during pregnancy and lactation. We also noted that the expression of epiregulin (EREG), an EGF family growth factor regulated directly by STAT5, is …
-
Identification and analysis of Il-2 induced Stat5 Target genes in Human CD4 and CD8 T cells
… the biological functions of STAT5 are well established from murine genetic<br/>studies, the downstream mediators of these proteins are poorly understood. In this study,<br/>an improved chromatin immunoprecipitation (ChIP)-cloning method, using magnetic<br/>microbeads for …
-
Novel Rac1/Stat3 and Stat5 Pathway in Differentiation and Neoplastic Transformation of Breast Epithelial Cells: Potential Prognostic Markers
… and Activator of Transcription (Stat)3 and Stat5 are transcription factors involved in normal breast development, and are hyperactivated in 30-50% of breast cancers. Stat5 is required for breast epithelial cell differentiation and is over-expressed in breast cancers with a more …
-
Mechanisms of Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression in Liver
… research was to determine whether additional STAT5 binding sites were involved in GH stimulation of IGF-I gene expression in liver. Sequence analysis of 170 kb of mouse genomic DNA revealed nineteen consensus STAT5 binding sequences corresponding to fourteen ~200 bp chromosomal regions that …
-
Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
… and activator of transcription (STAT) 3 and STAT5 are dephosphorylated and inactivated. Following sustained Src inhibition, STAT5 remains inactive, but Jak2 and STAT3 are reactivated following their early inhibition. To further characterize the mechanism of this novel feedback pathway we …
-
Growth Hormone and Nutritional Regulation of Insulin-Like Growth Factor-I Gene Expression
… transducer and activator of transcription 5 (STAT5) proteins, transcription factors that are known to be essential for GH-increased IGF-I gene expression. This 700 bp DNA region contains two STAT5-binding sites that appear to be conserved in mammals including cattle. Electrophoretic mobility …
-
Expression und Aufreinigung von intrazellulären Anteilen des Interleukin-4-Rezeptors als GST-Fusionsproteine und Messung von Protein-Protein-Wechselwirkungen
… gezeigt werden. Beide Proteine sind in der Lage, STAT5 zu präzipitieren; diese Bindung erscheint unabhängig von der IL-4 Stimulation der Zellen und läßt neue Spekulationen über den Mechanismus der Signaltransduktion durch STAT5 zu. Danach könnten nach den hier gewonnenen Informationen beide …
-
The regulation of the oncogenic STAT transcription factors by the non receptor tyrosine kinase and Cdc42 effector ACK
… This activation event is shown to drive STAT3, STAT5A and STAT5B nuclear translocation and transcriptional activation. Thus confirming ACK as a STAT activator. The ACK-STAT relationship is also demonstrated at an endogenous level, with a specificity to haematological disease cell lines. In the …
-
Untersuchungen zur Apoptoseregulation durch die Melanom induzierende Rezeptortyrosinkinase Xmrk
… der Src-Kinasen und der Transkriptionsfaktor STAT5. Um die Signaltransduktion von Xmrk in induzierbarer Form untersuchen zu können, wurde eine mit EGF stimulierbare Rezeptorchimäre HER-mrk, deren extrazellulärer Anteil vom humanen EGF-R und deren intrazellulärer Anteil von Xmrk stammt, in der …
-
Mechanisms of Erythroid Proliferation and Differentiation: Analysis of the Role of Erythropoietin Receptor in the Friend Virus Model
… transducer and activation of transcription 5 (STAT5), one of its downstream components, are required for Friend virus-induced polycythemia. Those evidence suggested a STAT5-dependent mechanism to regulate erythroid differentiation. Further studies showed that EPOR signaling has a novel role to …
-
Modeling Brk/PTK6 expression in the mammary epithelium.
… Signaling mediators downstream of Brk, including STAT5 and p38 MAPK were activated relative to wild-type mice. Brk-mediated signaling to STAT5 and p38 MAPK was recapitulated with Brk expression in non-transformed HC11 murine mammary epithelial cells. Additionally, non-transformed HMEC and HC11 …
-
Mechanisms of growth hormone inhibition of adipose tissue growth
… the central component of GH receptor signaling, STAT5, in GH inhibition of differentiation of bovine preadipocytes. In this study, preadipocytes were isolated from subcutaneous fat of adult cattle and were induced to differentiate with or without GH. Based on Oil Red O staining, gene expression, …
-
Local regulation of increased milk yield due to early lactation increased milking frequency
… transducer and activator of transcription 5 (STAT5), as well as a reduction in activated Akt (P ≤ 0.05). There was no difference in STAT3 expression at d 21. There was no significant difference in gene expression of prolactin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor …
-
Targeting the protein tyrosine phosphatase, SHP2, and PI3K in FLT3-ITD+ leukemia
… while having no effect on levels of phospho-STAT5. In transplants, C3H/HeJ mice injected with either WT-FLT3-, N51-FLT3-, or N51-Y768F-expressing cells showed that mutation of Y768 had no effect on overall survival. In addition, pharmacologic inhibition of Shp2 with II-B08 or PI3K with …
-
ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… of IgE-mediated tyrosine phosphorylation of STAT5, calcium mobilization, and degranulation. GRK2 inhibitors (paroxetine and its analog CCG258747) inhibited FcεRI-induced calcium mobilization and degranulation, and their intravenous administration in mice resulted in substantial reduction of …
Page 1 of 3