Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Stalled Forks"”.
-
The Fanconi anemia pathway and HELQ work alongside dormant replication origins to suppress replication-associated genome instability
… lesions that cause the stalling of replication forks. If left unchecked, this threatens the integrity of the genome and may be a driver of cancer development. Utilizing the <italic>Mcm4<super>chaos3</super></italic> mouse model, we found that dormant replication origins, which act as backup …
-
ZSCAN4 AND REPLICATION STRESS: SAFEGUARDING GENOME STABILITY IN MOUSE EMBRYONIC STEM CELLS
… RS slows down and eventually stalls replication forks. If stalled forks are not resolved, they can give rise to DNA double-strand breaks, thereby promoting genomic instability—a hallmark of cancer. Our laboratory discovered that exposure of mouse embryonic stem cells (mESC) to RS induces the …
-
Clarifying the Role of the CST Complex in DNA Replication and Repair
… helping facilitate replication re-start at stalled forks, activating checkpoint signaling at double-strand breaks, and promoting replication origin firing. Proper and efficient repair of DNA is critical in order to protect the integrity of the genome and prevent extreme mutagenesis. …
-
Npsd4: A New Player In Sumo-Dependent Dna Repair
… that NPSD4 plays a critical role in protecting stalled replication forks in response to replication stress. I showed that NPSD4 interacts with SUMO2/3 via two SUMO interacting motifs (SIMs). In addition, I found that NPSD4 is a nuclear protein and can localize to the SUMOylated promyelocytic …
-
Characterizing the Role of the E3 Ubiquitin Ligase Subunit MAEA in DNA Repair and Replication
… displayed inefficient DNA replication, increased stalled forks, difficulty restarting replication at fired origins, and a severe susceptibility to degradation following treatment with HU. These results comport with my earlier observations regarding increased DNA resection and decreased RAD51, both …
-
Flap Endonuclease 1 ensures telomere replication and stability
… of telomeres through its ability to re-initiate stalled replication forks. FEN1 depletion leads to telomere dysfunction characterized by the recognition of the telomeres as DNA double strand breaks and the specific loss of telomeres replicated by the lagging strand machinery. Expression of …