Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Stability testing"”.
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Dynamic stability testing with a wind tunnel magnetic model suspension system
Thesis: M.S., Massachusetts Institute of Technology, Department of Aeronautics and Astronautics, 1963
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The determination of drug stability by HPLC assay of degradation products.
This work evaluates the advantages in drug stability testing of following the decomposition by analysis of decomposition products. Conventional methods of drug stability testing are criticised and the limitations are shown to be largely a result of analysing for un-decomposed drug. Using simulated …
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Synthesis and engineering of metal-organic frameworks for liquid phase applications
… is insufficient data on their chemical stability as well as the lack of a standardised stability testing approach across literature. Thus, the aims of this work are two develop a comparable way of probing the water stability of MOFs as well as to test their applicability for …
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Preparation and Characterization Of Oil-in-water Nano-emulsions Of Trifluoperazine For Parenteral Drug Delivery
… parenteral delivery. 2.) To perform short term stability testing of the optimal formulation and monitor the potency using high performance chromatography (HPLC).</p><p> Materials and Methods: Emulsions containing soybean oil, water, trifluoperazine hcl as an amphiphilic drug, phospholipon 90 and …
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A comparative study of the thermal oxidative stability of high oleic acid sunflower and polyunsaturated soybean oil blends
The thermal oxidative stability was evaluated for 7 high oleic acid sunflower (HOSO) and polyunsaturated soybean oil (PUSB) blends ranging from 0.0% to 100.0% of each vegetable oil. Each blend was evaluated in quadruplicate over an eleven day period with 300 minutes of heating at 180°C per day. …
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Formulation and evaluation of diclofenac sodium dispersible tablets
… The four formulations were put on accelerated stability according to ICH guidelines for three months at 25°C/60%RH, 30°C/65%RH and 40°C/75%RH. HPLC was used to determine the identification, chromatographic purity and concentration of diclofenac sodium. Other tests included uniformity of mass, …
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State and Dynamics Estimation in an Outdoor Multi-Drone Slung Load System
… alongside a functional real world platform for testing load pose estimation methods. A novel cable-based testing apparatus that enables drone translation is used to facilitate stability testing of a quasi-static formation control method for lifting a slung load. This work aims to be the first to …
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The effect of additives on the molecular mobility, physical stability and dissolution of amorphous solid dispersions
… objectives were to (i) develop an accelerated testing method for predicting the solid-state physical stability of drugs in amorphous solid dispersions (ASD), (ii) gain a mechanistic understanding of the stabilization in the amorphous state brought about by small molecule excipients, and (iii) …
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Effect of a wet granulation manufacturing process on the stability of a pharmaceutical drug product
… root cause of low assay results observed during stability testing of a commercial drug product containing ethinyl estradiol and goes on to suggest improvements that could be made to the commercial manufacturing process to mitigate the stability issues. The potential for formation of different …
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Coupling qualitative and quantitative analyses of pharmaceutical materials enabled by second harmonic generation microscopy
… ingredient’s (API) crystal structure to stability testing and quality control, the phase of an API affects the solubility, bioavailability, stability, and efficacy of a drug product. Second harmonic generation (SHG) microscopy has recently been developed as a selective and rapid method …
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A modular simulation environment for the improved dynamic simulation of multirotor unmanned aerial vehicles
… behavior, for example for the design and stability testing of low-level control algorithms. However, the model is not able to properly represent more complicated three-dimensional airframes or realistic environmental effects like wind resistance or dynamic thrust. The thesis then outlines …
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Composition of Four Selected Arkansas-Grown Non-GMO Soybean Cultivars and the Development of High Protein Beverage Using a Selected Soybean Protein Hydrolysate
… increased the consumer acceptability. Shelf-life stability testing was at refrigerated storage (5 °C) over a 42 days period. Pasteurization (90-95 °C, 5 min) effectively prevented microbial growth. Turbidity increased significantly only in Chai tea drink, but not in tangerine and mixed berries …
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The formulation, testing and stability of 16% fat cream liqueurs
Cream liqueurs manufactured by a one-step process, where alcohol was added before homogenisation, were more stable than those processed by a two -step process which involved addition of alcohol after homogenisation. Using the one-step process, it was possible to produce creaming-stable liqueurs by …
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Novel carriers for oral delivery of hemophiliac factor IX
… the oral bioavailability of hFIX. We performed stability testing of lyophilized hFIX-loaded microparticles to determine the effects of storage conditions on hFIX release and activity. Lastly, in vivo biocompatibility and biodistribution studies were performed to establish the safety of multiple …
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Preparation and characterisation of Pt/C and Ni/C modified electrocatalysts for use towards the oxygen reduction reaction for proton exchange membrane fuel cells
… including underpotential deposition (UPD), MEA testing and stability testing
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Self-Assembled Host-Guest Thin Films for Functional Interfaces
… technique. The LB films were then subjected to stability testing using different solvents over increasing periods of time. Grazing-angle incidence X-ray diffraction (GIXD), specular X-ray reflectivity (XRR) and transfer ratio measurements were used to characterize the crystallinity, film …
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Lag screw effect on the biomechanical torsion stability in the I.S.I monocortical mandible angle system
In a recent in vitro biomechanical stability study by F.J. Jacobs, a unique, patented inclined screw insertion (I.S.I.) mandibular angle, intra-oral trauma-plate was evaluated for torsion and compression stability and compared to conventional plating of simulated angle fractures in polyurethane …
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Evaluation of dynamic light scattering as a technique for the routine monitoring of therapeutic proteins on stability
… and drug product (DP) release, as well as for stability testing, the ICH guidelines reference SEC as an example. However, it is acknowledged that new analytical techniques are continuously being developed and can be used where appropriate. Dynamic Light Scattering (DLS) is one such technique, …
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Development and evaluation of new leprosy skin test antigens as diagnostic tools
… and MLCwA, were developed for manufacturing and testing for safety and efficacy in phase I and phase II human clinical trials. Skin test antigens were derived from M. leprae purified from experimentally infected armadillo tissues under current good manufacturing practice conditions. A skin test …
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Resveratrol Nanostructured Lipid Carrier for targeted delivery to breast cancer
… and the components of the formulation. Undertake stability studies for the formulated RES-NLCs, at various storage conditions in order to select the most stable formulation and take it for further functionalization with targeting ligands hyaluronic acid; HA-NLCs, folic acid; FA-NLCs and dual …
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