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Showing 1 to 6 of 6 for “"Sse1"”.
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Analysis of The Biochemical and Cellular Activities of Substrate Binding By The Molecular Chaperone Hsp110/Sse1
… Hsp110 is represented by the proteins Sse1 and Sse2, which possess an Hsp70-like substrate binding domain (SBD), making them unique among other functionally similar, but structurally distinct, NEFs. Studies of Hsp110 and Sse1 have demonstrated that this chaperone/NEF family can bind …
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Mutational analysis of Hsp110 suggests an integral role for the chaperone in yeast prion propagation.
… have demonstrated how the Hsp110 proteins Sse1 and Sse2 are necessary for promoting the propagation of the yeast prions [PSI+] and [URE3]. A group of Sse1 mutants with impaired ability to propagate [PSI+] were created. These mutants were characterised according to the degree in which they …
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Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks In Yeast
… factors (NEFs) homologous to human counterparts; Sse1/Sse2/HSP110, Fes1/HspBP1, and Snl1/Bag1. In an effort to understand the differential functional contributions of the cytosolic NEFs to protein homeostasis (“proteostasis”), I carried out comparative genetic, biochemical and cell biological …
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Elucidation of the role of the linker motifs of Plasmodium falciparum Hsp70-1 and Hsp70-z
… most studied Hsp110, Saccharomyces cerevisiae Sse1. To date, the function of the linkers of Hsp110s and PfHsp70-1 largely remains unknown. By creating linker swap versions of PfHsp70-1 and PfHsp70-z, this study sought to elucidate the roles of the linkers of the two chaperones in modulating …
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Deciphering The Role of Hsp110 Chaperones In Diseases of Protein Misfolding
… <em>Saccharomyces</em> <em>cerevisiae</em>SSE1. Furthermore, the human Hsp110s, Apg-1 and Hsp105α, also contain a C-terminal extension substrate binding region, indicating this site may be conserved among some metazoans. Upon further analysis, I determined C-terminal extension chaperoning …
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Biochemical Characterization of Binding Partners of Two Hsp70 Co-Chaperones In Saccharomyces Cerevisiae
… non-related cytosolic NEFs are present: Sse1 (Hsp110), Fes1 (HspBP1) and Snl1 (Bag-1). Snl1 is unique among the cytosolic NEFs as it is localized at the ER membrane with its Hsp70 binding (BAG) domain exposed to the cytosol. I discovered that Snl1 distinctly interacts with assembled …