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Showing 1 to 10 of 10 for “"Ssa1"”.
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Deciphering Functional Significance of Substrate-Binding Domain of Ssa1 on Heat-Shock Response and Prion Propagation
… size as too large, such as tryptophan, Ssa1 will lose intrinsic function and fail to support cell viability. By contrast, residue 483 prefer to smaller size amino acid to remain the hydrophobic core of SBD. Therefore, mutations on those two residues easily disturb the integrity of SBD …
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Redox Sensing By Yeast Hsp70 Facilitates Modulation of Protein Quality Control and The Cytoprotective Response
… of cysteine modification on the Hsp70 Ssa1 in budding yeast, I generated cysteine null (cysteine to serine) and oxidomimetic (cysteine to aspartic acid) mutant variants of both C264 and C303 and demonstrate reduced ATP binding, hydrolysis and protein folding properties in both the …
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A study of the super-abundant Bemisia tabaci (Gennadius) species complex (Hemiptera: Aleyrodidae) in cassava mosaic disease pandemic areas in Tanzania
… on mitochondrial data were sub-Saharan Africa 1 (SSA1), Mediterranean (MED), Indian Ocean (IO) and East Africa 1 (EA1). There were four sub-groups (SG) under SSA1 which included SSA1-SG1, SSA1-SG2, SSA1-SG1-2 and SSA1-SG3. SSA1-SG1 was found to be the pandemic-associated B. tabaci in Tanzania, …
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Hsp70-Mediated Regulation of Hsf1 Transcriptional Activity In Saccharomyces Cerevisiae
… cerevisiae</em> have shown that the Hsp70 Ssa1 acts as a sensor for some proteotoxic stresses and is capable of a direct interaction with Hsf1. This work continues to explore the complex regulatory interaction between Hsf1 and Ssa1. I found that the Ssa1 substrate binding domain recognizes …
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Assessing the role of Hsp70 in prion propagation in Saccharomyces cerevisiae
… the major cytosolic Hsp70 chaperones of yeast, Ssa1-4 which impair the propagation of [PSI+]. A majority of isolated mutants are located within the ATPase domain and have no significant affect on Hsp70 function. The PBD mutant Ssa1F475S, which impairs [PSI+] propagation also appears to make Ssa1 …
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Diversity and role of bacterial endosymbionts infecting the cassava whitefly, Bemisia tabaci (Gennadius) in Sub-Saharan Africa
… colonies of sub-Saharan Africa 1-subgroup 3 (SSA1-SG3), infected with Arsenophonus and Rickettsia (AR+) and those free of AR (AR-) were compared for fecundity, nymph development, adult emergence and development time on healthy and East African cassava mosaic virus-Uganda (EACMV-UG)-infected …
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Regulation of The Heat Shock Response By Thiol-Reactive Compounds In The Yeast Saccharomyces Cerevisiae
… <em>in vitro </em>that the yeast cytosolic Hsp70 Ssa1, which partners with Hsp90 to repress Hsf1, is specifically modified. Strikingly, mutation of conserved cysteine residues in Ssa1 renders cells insensitive to Hsf1 activation by cadmium and celastrol but not by heat shock. Conversely, …
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Stress-Induced Targeting of Molecular Chaperones In The Yeast Saccharomyces Cerevisiae
… that Hsp104, along with the Hsp70 chaperone, Ssa1, and the sHSP Hsp26 accumulate into RNA processing bodies (P- bodies) and stress granules, sites of mRNA metabolism. I found that Hsp104 recruits both Ssa1 and Hsp26 to P-bodies and that these three chaperones are required for stress granule …
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Propuesta de un manual de procedimientos para la preparación de una mezcla de nutrición parenteral en el servicio de farmacia del Hospital Nacional de la Mujer "Dra. María Isabel Rodríguez"
… dados por la Norma Oficial Mexicana NOM-249-SSA1-2010, Mezclas Estériles: nutricionales y Medicamentosas e Instalaciones para su Preparación (de aquí en adelante “la Norma Mexicana”) la cual se ha tomado como parámetro para la preparación de este tipo de mezclas nutricionales para que el …
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Energy Stress Causes Chaperones to Assemble Into Cytoplasmic Complexes
… I have observed Hsp104, Hsp26, and Hsp42 but not Ssa1 form into cytoplasmic foci. As the Q-bodies are hypothesized to be involved in protein refolding or degradation, the starvation-induced bodies may also play a crucial role in protein quality control. The overall goal of my project was to …