Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Srsf3"”.
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Identification des changements cellulaires déclenchés en conditions pathologiques aiguë et chronique du système cardiovasculaire par des approches à haut débit
… a permis d’identifier pour la première fois Srsf3, une protéine ayant une fonction l’épissage de l’ARNm constitutif et alternatif. Un aspect fonctionnel de p38α sur Srsf3 a été révélé sur sa fonction d’épissage. Les rôles de Srsf3 étant peu connus au niveau cardiaque, ces résultats ont motivé …
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Differential Impact of VEGF and FGF2 Signaling Mechanisms on Flt1 Pre-mRNA Splicing
… and identified two candidate proteins, SRSF2 and SRSF3, that may be involved in VEGF- or FGF2-induced Flt1 pre-mRNA splicing. Examination of SRSF2 and SRSF3 relative mRNA expression levels, following inhibition of VEGF- and FGF2-activated kinases, indicates that FGF2 significantly downregulates …
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Mutational Landscape of Noncoding Ultraconserved Elements in Human Cancers: Functional Relevance and Clinical Utility
… processing of the pre-miR-142 by preventing SRSF3 binding to the CNNC motif in the 3p flanking sequence, resulting in a downregulation of the mature sequences of miR-142. To explore potential clinical utility, we develop a targeted UCE sequencing assay and characterize well-annotated tumor …
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Long-read transcriptome profiling of germinal centre B cells
… splicing factors (SRSF) (e.g., SRSF3 and SRSF7). Naive B cells preferentially expressed isoforms carrying PE, leading to nonsense-mediated mRNA decay, whilst the PE were preferentially removed in activated and GC B cells. Notably, we found this regulation of PE in splicing …